Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here, we evaluated whether four single nucleotide polymorphisms (SNPs), located within ITGAM, were associated with SLE and RA susceptibility in patients from Mexico.
|
31774828 |
2019 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, single nucleotide polymorphisms in ITGAM, TNFSF4, TNFAIP3 and STAT4 genes are associated with susceptibility to SLE in a North Indian population.
|
30041578 |
2018 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The Mac-1 rs1143679 lupus-risk variant reverses Mac-1 inhibition of FcγRIIA, as does a Mac-1 ligand and a mutation in Mac-1's ligand binding αI-domain.
|
30498196 |
2018 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Conclusion CD11b rs1143679 appears to be associated with risk for SLE in the Han Chinese population, and may play an important role in the development of lupus nephritis.
|
29207897 |
2018 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
CD11b also modulates other signaling pathways in these cells, such as the Toll-like receptor signaling pathways, that mediate generation of type I interferons, a key proinflammatory cytokine and circulating biomarker in SLE and LN patients.
|
29600248 |
2018 |
Lupus Erythematosus, Systemic
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
CD11b expression was reduced in SLE women (RLU): granulocytes, 588 versus 1448.5 (P < 0.001); monocytes, 1017 versus 1619 (P = 0.002).
|
28464513 |
2017 |
Lupus Erythematosus, Systemic
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
This suggests that pharmacologic activation of CD11b could be a potential mechanism for developing SLE therapeutics.
|
28263189 |
2017 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have identified several ITGAM (α<sub>M</sub> subunit) single nucleotide polymorphisms that are associated with systemic lupus erythematosus.
|
27974454 |
2017 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in ITGAM are among the strongest risk factors for systemic lupus erythematosus, an autoimmune disease characterized by the presence of autoantibodies.
|
28407558 |
2017 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The rs1143679" genes_norm="3684">R77H variant of CD11b, encoded by the ITGAM rs1143679 polymorphism, is associated robustly with development of the autoimmune disease systemic lupus erythematosus (SLE) and impairs CR3 function, including its regulatory role on monocyte immune signalling.
|
27118513 |
2016 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.
|
26606652 |
2016 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This includes a detailed examination of molecular mechanisms that could explain the risk-conferring effect of rs1143679, a single nucleotide non-synonymous Mac-1 polymorphism associated with SLE.
|
26683153 |
2016 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
IFN-γ licenses CD11b(+) cells to induce progression of systemic lupus erythematosus.
|
26094774 |
2015 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analyses confirm that the ITGAM rs1143679 polymorphism is associated with SLE susceptibility in different ethnic groups and demonstrate that the polymorphism is associated with LN in European.
|
25315704 |
2015 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We resequenced ITGAM in 73 SLE cases and identified two previously unidentified, case-specific nonsynonymous variants, F941V and G1145S.
|
24886912 |
2014 |
Lupus Erythematosus, Systemic
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of ITGAM mRNA was significantly decreased in SLE patients compared with healthy controls (P = 0.007).
|
23708937 |
2014 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This two-pronged contribution (nucleic acid- and protein-level) of the rs1143679 risk allele to decreasing ITGAM activity provides insight into the molecular mechanisms of its potent association with SLE.
|
24608226 |
2014 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We assessed whether the variant rs1143679" genes_norm="3684">R77H, rs1143679 within ITGAM, is associated with the risk to developing SLE and the clinical manifestations of Brazilian SLE patients.
|
24269694 |
2014 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
Lupus Erythematosus, Systemic
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Genetics and epigenetics of systemic lupus erythematosus.
|
23943494 |
2013 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |