ITGAM, integrin subunit alpha M, 3684

N. diseases: 343; N. variants: 14
Disease: Mechanical Allodynia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.030 Biomarker phenotype BEFREE Intrathecal injection of Mac-1-saporin (a saporin-conjugated anti-mac1 antibody) resulted in a decreased number of microglia and attenuated both mechanical allodynia and thermal hyperalgesia in HFD-fed mice. 31108168 2019
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.030 AlteredExpression phenotype BEFREE Depletion of microglia using Mac-1-saporin partially prevented IL-6 up-regulation and attenuated VRT-induced bilateral mechanical allodynia. 29423951 2018
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.030 AlteredExpression phenotype BEFREE The results showed that SNI produced mechanical allodynia and depressive-like behaviors, and also increased the expressions of microglia markers (Iba1, CD11b) and M1 markers (CD68, iNOS, IL-1β, TNF-α, and 8-OH-dG) in the prefrontal cortex. 28458629 2017