ITGB2, integrin subunit beta 2, 3689

N. diseases: 340; N. variants: 31
Disease: Alveolar Bone Loss ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002382
Disease: Alveolar Bone Loss
Alveolar Bone Loss 		0.010 Biomarker disease BEFREE Local treatment with antibodies to IL-17 or IL-23 in LFA-1-deficient mice not only blocked inflammatory periodontal bone loss but also caused a reduction in the total bacterial burden, suggesting that the IL-17-driven pathogenesis of LAD-I periodontitis leads to dysbiosis. 24670684 2014