ITGB2, integrin subunit beta 2, 3689

N. diseases: 340; N. variants: 31
Disease: Dermatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011603
Disease: Dermatitis
Dermatitis 		0.330 Biomarker disease BEFREE Similar to IL-17 or IL-23/p19 depletion, injection of diseased CD18(hypo) PL/J mice with anti-γδTCR Abs significantly reduced skin inflammation and largely eliminated pathological γδ and CD4(+) T cells. 24190659 2013
CUI: C0011603
Disease: Dermatitis
Dermatitis 		0.330 Biomarker disease BEFREE Adoptive transfer of CD18(-/-) PL/J splenocytes into skin disease-resistant CD18(+/-) PL/J mice failed to induce skin inflammation. 14734620 2004
CUI: C0011603
Disease: Dermatitis
Dermatitis 		0.330 Biomarker disease BEFREE However, Itgb2(tm1Bay)/Itgb2(tm2Bay) PL/J mice developed dermatitis indistinguishable from Itgb2(tm1Bay) PL/J mice. 12819024 2003
CUI: C0011603
Disease: Dermatitis
Dermatitis 		0.330 Biomarker disease CTD_human Homozygous CD18 null mice develop chronic dermatitis with extensive facial and submandibular erosions. 9653089 1998