ITGB2, integrin subunit beta 2, 3689

N. diseases: 340; N. variants: 31
Disease: Down Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.030 AlteredExpression disease BEFREE Moreover, the relative expression of CD18 on T and B cells (previously and not previously reported, respectively) were elevated in DS children (p⩽0.01). 27166175 2016
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.030 Biomarker disease BEFREE We have now developed a computer model that compares the observed and predicted CD18 flow cytometric profiles for trisomy 21 LCL. 1979957 1990
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.030 AlteredExpression disease BEFREE These results suggest that the increase in CD18 expression by Trisomy 21 cells is due to gene dosage, and could influence the immune status of persons with Down syndrome. 2964960 1988