ITGB2, integrin subunit beta 2, 3689

N. diseases: 340; N. variants: 31
Disease: Herpes Simplex Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.020 Biomarker group BEFREE Here, we demonstrate that on infection of human monocyte-derived DCs with herpes simplex virus type 1 (HSV-1), CYTIP is rapidly degraded and as a consequence β-2 integrins, predominantly LFA-1, are activated. 21562043 2011
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.020 Biomarker group BEFREE In each model, MC from patients with "severe" or "moderate" phenotypes of Mac-1 deficiency, or normal MC incubated with a combination of anti-LFA-alpha, Mac-1-alpha, p150,95-alpha plus -beta MAb failed to protect neonatal mice against lethal HSV infection. 3528287 1986