ITGB3, integrin subunit beta 3, 3690

N. diseases: 260; N. variants: 44
Disease: Alloimmunisation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948201
Disease: Alloimmunisation
Alloimmunisation 		0.030 GeneticVariation disease BEFREE Among central Europeans polymorphisms of GPIIIa, GPIb, GPIIb, and GPIa named human platelet antigen-1 (HPA-1), -2, -3, and -5 are the clinically most relevant systems in which alloimmunization occurs. 9684730 1998
CUI: C0948201
Disease: Alloimmunisation
Alloimmunisation 		0.030 Biomarker disease BEFREE Maternal DRB1*1501, DQA1*0102, DQB1*0602 haplotype in fetomaternal alloimmunization against human platelet alloantigen HPA-6b (GPIIIa-Gln489). 9271820 1997
CUI: C0948201
Disease: Alloimmunisation
Alloimmunisation 		0.030 Biomarker disease BEFREE This study shows that the GST/N-terminal GPIIIa fusion proteins contain conformational epitopes that mimic those involved in alloimmunization, and that regions other than the amino terminal 66 amino acids of GPIIIa are not likely to contain or be required for the development of functional PlA1 epitopes. 7519475 1994