Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 GeneticVariation disease GWASCAT Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression. 30626913 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 GeneticVariation disease GWASCAT Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect. 30285260 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 GeneticVariation disease GWASCAT Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. 29483656 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 GeneticVariation disease GWASCAT Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 28540026 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 GeneticVariation disease BEFREE Common single nucleotide polymorphisms (SNPs) in or near the inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) gene have been repeatedly associated with schizophrenia and related psychiatric disorders in genome-wide association studies. 27396837 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 Biomarker disease BEFREE The successful replication of this finding in a different ethnic group provides stronger evidence for the association between schizophrenia and ITIH3/4. 26206863 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 Biomarker disease PSYGENET After combining the new schizophrenia data with those of the PGC, variants at three loci (ITIH3/4, CACNA1C and SDCCAG8) that had not previously been GWS in schizophrenia attained that level of support. 22614287 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 GeneticVariation disease GWASDB Genome-wide association analysis identifies 13 new risk loci for schizophrenia. 23974872 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 GeneticVariation disease GWASCAT Genome-wide association analysis identifies 13 new risk loci for schizophrenia. 23974872 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 GeneticVariation disease GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 Biomarker disease BEFREE Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. 22614287 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.440 GeneticVariation disease BEFREE Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. 21926972 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.410 GeneticVariation disease GWASCAT Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression. 30626913 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.410 GeneticVariation disease BEFREE We detected a novel association between suicide attempt and the ITIH3/4-region in a combined group of patients with BD, SCZ and related psychosis spectrum disorders. 24461634 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.410 Biomarker disease PSYGENET STAB1 is located in close proximity to PBMR1 and the NEK4-ITIH1-ITIH3-ITIH4 region, which are the top findings from GWAS meta-analyses of mood disorder, and a combined BD and schizophrenia data set. 25136889 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.410 Biomarker disease PSYGENET We detected a novel association between suicide attempt and the ITIH3/4-region in a combined group of patients with BD, SCZ and related psychosis spectrum disorders. 24461634 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.410 GeneticVariation disease GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.410 GeneticVariation disease GWASDB Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. 23070075 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.410 Biomarker disease PSYGENET In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10(-9)), ANK3 (rs10994359, P = 2.5 × 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10(-9)). 21926974 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.410 Biomarker disease PSYGENET Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. 21926972 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.300 Biomarker disease CTD_human Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression. 19363144 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.110 GeneticVariation disease GWASCAT Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression. 30626913 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.110 Biomarker disease BEFREE Three samples with major depressive disorder (total=671) were genotyped for 44 SNPs in 8 candidate genes (CACNA1C, CACNB2, ANK3, GRM7, TCF4, ITIH3, SYNE1, FKBP5). 28989100 2018
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.110 GeneticVariation disease BEFREE We examined the association between the selected polymorphisms in two candidate genes, the arsenite methyltransferase gene (AS3MT, rs11191454) and the inter-α-trypsin inhibitors heavy chain-3 gene (ITIH3, rs2535629), and attention-deficit hyperactivity disorder (ADHD) in a Korean population. 25461954 2015
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.110 GeneticVariation disease GWASDB Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013