ITK, IL2 inducible T cell kinase, 3702

N. diseases: 117; N. variants: 12
Disease: Asthma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.040 Biomarker disease BEFREE Inhibition of Bruton's tyrosine kinase and IL-2 inducible T-cell kinase suppresses both neutrophilic and eosinophilic airway inflammation in a cockroach allergen extract-induced mixed granulocytic mouse model of asthma using preventative and therapeutic strategy. 31505252 2019
CUI: C0004096
Disease: Asthma
Asthma 		0.040 GeneticVariation disease BEFREE People with the -rare allele 196C>T may be more susceptible to asthma via transcriptional regulation of the ITK gene. 21323647 2011
CUI: C0004096
Disease: Asthma
Asthma 		0.040 Biomarker disease LHGDN Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration. 18322190 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.040 Biomarker disease BEFREE We assessed the role of polymorphisms in the TIM family genes and ITK in atopy, eczema, and asthma. 16159638 2005