JAG2, jagged canonical Notch ligand 2, 3714

N. diseases: 81; N. variants: 2
Disease: Multiple Myeloma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 Biomarker disease BEFREE Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance. 31582544 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 AlteredExpression disease BEFREE Cultivation of MM-BMMSCs with increasing levels of recombinant jagged-2 reduced miR-223 and increased Hes1 levels in a concentration-dependent manner. 27023728 2016
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 PosttranslationalModification disease BEFREE We showed that the JAG2 promoter region is aberrantly acetylated in MM cell lines and patient samples. 19417136 2009
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 AlteredExpression disease BEFREE Taken together, these results indicate that JAG2 overexpression may be an early event in the pathogenesis of multiple myeloma involving IL-6 production. 15292061 2004