JAK1, Janus kinase 1, 3716

N. diseases: 239; N. variants: 41
Disease: Constitutional Symptom ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009812
Disease: Constitutional Symptom
Constitutional Symptom 		0.030 Biomarker phenotype BEFREE Ruxolitinib (Rux), a Jak1/2 inhibitor, results in reduced spleen size and improvement in constitutional symptoms in the majority of patients with myelofibrosis (MF). 30962501 2020
CUI: C0009812
Disease: Constitutional Symptom
Constitutional Symptom 		0.030 Biomarker phenotype BEFREE In a CMML patient with splenomegaly, who was treated with the JAK1/2 inhibitor ruxolitinib off label, we can demonstrate a spleen response and the disappearance of constitutional symptoms which was associated with a decrease in autonomous CFU-GM formation ex vivo. 27157043 2016
CUI: C0009812
Disease: Constitutional Symptom
Constitutional Symptom 		0.030 Biomarker phenotype BEFREE Clinical trials demonstrated that JAK1/2 inhibitors ameliorate constitutional symptoms and reduce spleen size in patients with myelofibrosis. 23313046 2013