Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1261473
Disease: Sarcoma
Sarcoma 		0.310 GenomicAlterations group CGI
CUI: C0029607
Disease: Other emphysema
Other emphysema 		0.200 Biomarker phenotype MGD
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.050 Biomarker disease BEFREE Finally, this study identified a breakpoint at 1p32 that was localized between the genes JUN and MYCL for one neuroblastoma thus establishing the order of these genes as centromere, JUN, MYCL, telomere. 2776489 1989
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.050 Biomarker disease BEFREE Finally, this study identified a breakpoint at 1p32 that was localized between the genes JUN and MYCL for one neuroblastoma thus establishing the order of these genes as centromere, JUN, MYCL, telomere. 2776489 1989
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.050 Biomarker disease BEFREE Finally, this study identified a breakpoint at 1p32 that was localized between the genes JUN and MYCL for one neuroblastoma thus establishing the order of these genes as centromere, JUN, MYCL, telomere. 2776489 1989
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.020 AlteredExpression disease BEFREE Expression of proto-oncogene c-jun during differentiation of B-chronic lymphocytic leukemia. 2113601 1990
CUI: C0024198
Disease: Lyme Disease
Lyme Disease 		0.020 Biomarker disease BEFREE Ninety-four serum specimens from patients having Lyme borreliosis were tested for reactivity with P39. 2380361 1990
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE It recently has been reported that certain nuclear receptors can antagonize the tumor promoter 12-O-tetradeconylphorbol-13-acetate (TPA) by direct interaction with the transcription factor AP-1, and that the AP-1 constituents cJun and cFos can inhibit receptor activity. 1791843 1991
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.050 AlteredExpression phenotype BEFREE The proto-oncogene C-jun acts as a transcriptional activator or repressor for numerous cellular genes, and the overexpression of these genes may cause malignant transformation. 1404666 1992
CUI: C0023470
Disease: Myeloid Leukemia
Myeloid Leukemia 		0.030 AlteredExpression disease BEFREE The present work demonstrates that treatment of human myeloid leukemia cells (HL-60, U-937, and KG-1) with CDDP is associated with increased expression of the c-jun gene and that this effect is related to activation by a transcriptional mechanism. 1737349 1992
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.020 AlteredExpression disease BEFREE We investigated the expression of jun genes in renal cell cancer (RCC) and their regulation by cytokines and transforming growth factor beta 1 (TGF-b1). 1404666 1992
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 AlteredExpression disease BEFREE Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis. 8314777 1993
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis. 8314777 1993
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 AlteredExpression disease BEFREE The possibility that the hbx protein may activate certain protooncogenes was investigated and we found that hbx can activate the protooncogene c-jun promoter. c-Jun was found to be expressed at a very low level in normal liver tissue but at high levels in HCCs of HBV-infected patients. 8390762 1993
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.350 Biomarker disease BEFREE The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines. 8076631 1994
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.300 Biomarker disease CTD_human Differential expression of c-jun, c-fos and hsp 70 mRNAs after folic acid and ischemia-reperfusion injury: effect of antioxidant treatment. 7922267 1994
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.300 Biomarker disease CTD_human Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. 7984056 1994
CUI: C0270823
Disease: Petit mal status
Petit mal status 		0.300 Biomarker disease CTD_human Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. 7984056 1994
CUI: C0311335
Disease: Grand Mal Status Epilepticus
Grand Mal Status Epilepticus 		0.300 Biomarker disease CTD_human Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. 7984056 1994
CUI: C0393734
Disease: Complex Partial Status Epilepticus
Complex Partial Status Epilepticus 		0.300 Biomarker disease CTD_human Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. 7984056 1994
CUI: C0751522
Disease: Status Epilepticus, Subclinical
Status Epilepticus, Subclinical 		0.300 Biomarker disease CTD_human Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. 7984056 1994
CUI: C0751523
Disease: Non-Convulsive Status Epilepticus
Non-Convulsive Status Epilepticus 		0.300 Biomarker disease CTD_human Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. 7984056 1994
CUI: C0751524
Disease: Simple Partial Status Epilepticus
Simple Partial Status Epilepticus 		0.300 Biomarker phenotype CTD_human Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. 7984056 1994
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.030 Biomarker disease BEFREE The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines. 8076631 1994
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.030 Biomarker disease BEFREE The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines. 8076631 1994