|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Ether-à-go-go-1 (Eag1) is an ion channel that plays important roles in tumour proliferation, malignant transformation, invasion, metastasis, recurrence, and prognosis.
|
30362536 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of EAG1 channels in tumor development and its therapeutic significance have been well established.
|
28367272 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Eag1 plays important roles in tumor proliferation, malignant transformation, invasion, metastasis, recurrence, and prognosis.
|
28160046 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The human ether-à-go-go channel (hEag1 or K<sub>V</sub>10.1) is a cancer-relevant voltage-gated potassium channel that is overexpressed in a majority of human tumors.
|
28902151 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The concomitant administration of calcitriol and astemizole inhibited tumor growth more efficiently than each drug alone, which may be explained by the blocking of EAG1.
|
25280486 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This study provides insight into the molecular mechanisms involved in astemizole-calcitriol combined antineoplastic effect, offering scientific support to test both compounds in combination in further preclinical and clinical studies of neoplasms expressing VDR and Eag1.
|
22984610 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings strongly support the notion that hEAG1 may represent a promising candidate as tumor marker and membrane therapeutic target for HNSCC treatment.
|
22466864 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our results suggest that Eag1 silencing inhibits tumor growth and angiogenesis in osteosarcoma via the down regulation of VEGF/PI3K/AKT signaling.
|
23202914 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Their potential role in EMT might not be uniquely related to their conducting function, in accordance with the reported tumor growth supported by non-conducting EAG1 channels.
|
21508374 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Consequently, we studied Eag1 protein expression by immunochemistry in cervical cancer cell lines, normal keratinocytes, cervical cytologies from intraepithelial lesions, biopsies from cervical intraepithelial neoplasias (CIN 1, 2 and 3) and in normal smears from patients taking or not taking estrogens.
|
21887469 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Inhibition of Eag1 expression in tumour cell lines reduced cell proliferation.
|
17022810 |
2006 |