Ventricular arrhythmia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study focuses on investigating the potential variants on SCN5A, KCNQ1, and KCNH2 contributing to AMI with VA in a Chinese population.
|
31751991 |
2020 |
Ventricular arrhythmia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Slow heart rate-induced PVC alternans was observed in experiments of transgenic LQT2 rabbits under isoproterenol, which was associated with increased APD dispersion and spontaneous occurrence of ventricular arrhythmias, in agreement with the theoretical predictions.
|
29377142 |
2018 |
Ventricular arrhythmia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to QT interval shortening and ventricular arrhythmias, SQT1 is associated with increased risk of atrial fibrillation (AF), which is often the only clinical presentation.
|
30687112 |
2018 |
Ventricular arrhythmia
|
0.100 |
Biomarker
|
disease |
BEFREE |
LQT2 is associated with fatal ventricular arrhythmias promoted by triggered activity in the form of early afterdepolarizations (EADs).
|
30173888 |
2018 |
Ventricular arrhythmia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to characterize the EMW as a marker for drug-induced ventricular arrhythmias in anesthetized rabbit model of long QT syndrome type 2 (LQT2) and short QT syndrome (SQTS) infused with reference compounds known to lengthen or shorten QT intervals.
|
28904293 |
2017 |
Ventricular arrhythmia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ventricular arrhythmias as a result of unintentional blockade of the Kv11.1 (hERG [human ether-à-go-go-related gene]) channel are a major safety concern in drug development.
|
27071825 |
2016 |
Ventricular arrhythmia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Long QT syndrome type 2 (LQT2) is an autosomal dominant disorder caused by mutations in hERG, and patients with LQT2 are susceptible to severe ventricular arrhythmias.
|
23997099 |
2013 |
Ventricular arrhythmia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
KCNH2 mutations cause type 2 long QT syndrome (LQT2), which increases the risk for life-threatening ventricular arrhythmias.
|
23546015 |
2013 |
Ventricular arrhythmia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations in KCNH2 (the gene that encodes hERG1) causes LQT2, one of the most common forms of long QT syndrome, a disorder of cardiac repolarization that predisposes affected subjects to ventricular arrhythmia and increases the risk of sudden cardiac death.
|
20544339 |
2010 |
Ventricular arrhythmia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ion channels encoded by the human ether-a-go-go-related gene (HERG) give rise to the rapidly activating delayed rectifier K+ current (IKr), the perturbation of which causes ventricular arrhythmias associated with inherited and acquired long QT syndrome.
|
19726880 |
2009 |
Ventricular arrhythmia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Type 2 congenital long QT syndrome (LQT-2) is linked to mutations in the human ether a-go-go-related gene (HERG) and is characterized by rate-corrected QT interval (QTc) prolongation, ventricular arrhythmias, syncope, and sudden death.
|
18551196 |
2008 |
Ventricular arrhythmia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Despite a critical need to minimize drug effects on hERG, one should always keep in mind that hERG is not the only structural correlate of QT prolongation, and that QT prolongation is a sub-optimal biomarker for ventricular arrhythmia and fibrillation.
|
18782006 |
2008 |
Ventricular arrhythmia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the potassium channel encoded by the human ether-a-go-go-related gene (HERG) have been linked to the congenital long QT syndrome (LQTS), a cardiac disease associated with an increased preponderance of ventricular arrhythmias and sudden death.
|
12885765 |
2003 |
Ventricular arrhythmia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This review summarizes current findings about mutations causing LQT2, the mechanisms by which mutations may cause the clinical phenotype of a reduction in I(Kr) and a prolonged QT interval, and how this may be involved in the generation of ventricular arrhythmias.
|
11196567 |
2000 |
Ventricular arrhythmia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in HERG or KVLQT1 genes predispose affected individuals to ventricular arrhythmias and sudden death.
|
9476573 |
1997 |