|
cardiac event
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, these cardiac events during the postpartum period are more common in patients with LQT2.
|
27054604 |
2018 |
|
cardiac event
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Multivariate analysis identified proband status and QTc > 500 ms as predictors of cardiac events in all three genotypes, and males <14 years and females >14 years as predictors of cardiac events in LQT1 and LQT2 only.
|
29504689 |
2018 |
|
cardiac event
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
LQT2 (compared to LQT1), female gender, a cardiac event before age 18, and long QT interval increased the risk of cardiac events in LQTS patients aged 18 to 40 years.
|
29622001 |
2018 |
|
cardiac event
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The risk of cardiac events in LQT2 carriers with normal QTc is associated with abnormal T-wave morphology in women and pore location of mutation in men.
|
30012873 |
2018 |
|
cardiac event
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The risk of cardiac events was significantly lower in LQT1 girls than boys≤12 years (HR, 0.55), whereas LQT2 female patients ≥13 years had the higher risk of cardiac events than male patients (HR, 4.60).
|
26823142 |
2016 |
|
cardiac event
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The duos were composed of 2 relatives harboring the same heterozygous KCNQ1 or KCNH2 mutation: 1 with cardiac events and 1 asymptomatic and untreated.
|
23856471 |
2013 |
|
cardiac event
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Only T-roundness complemented QTc in the model investigating cardiac events in LQT2.
|
21315844 |
2011 |
|
cardiac event
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In 118 genetically-confirmed LQT2 patients (69 families, 62 KCNH2 mutations), the ECG parameters, Schwartz scores, and the incidence of cardiac events, defined as syncope, aborted cardiac arrest, and sudden cardiac death, were evaluated.
|
18441445 |
2008 |
|
cardiac event
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
It has been proposed that the highest risk for cardiac events in patients with long-QT syndrome subtype 2 (LQT2) is related to mutations in the pore region of the KCNH2 channel.
|
15699249 |
2005 |
|
cardiac event
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Along with previous gene-specific associations involving swimming and LQT1 as well as auditory triggers and LQT2, this association between postpartum cardiac events and LQT2 can facilitate strategic genotyping.
|
15851119 |
2004 |
|
cardiac event
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Recent data showed that long QT syndrome (LQTS) patients with mutations in the pore region of the HERG (LQT2) gene have significantly higher risk of cardiac events than subjects with mutations in the non-pore region.
|
14678125 |
2003 |
|
cardiac event
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The QTc duration and the frequency of cardiac events (syncope and LQTS-related cardiac arrest/death) were similar among carriers with the five HERG mutations.
|
11844290 |
2002 |
|
cardiac event
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The risk varies by age among 3 genetic types of LQTS: LQT1 carriers are at higher risk of cardiac events between age 5 to 15 years than below age of 5 years, LQT2 carriers have the highest risk of cardiac events at age 10 to 15, and LQT3 carriers have infrequent cardiac events below age of 10 years.
|
11781951 |
2001 |
|
cardiac event
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
C-terminal HERG mutations: the role of hypokalemia and a KCNQ1-associated mutation in cardiac event occurrence.
|
10086971 |
1999 |
|
cardiac event
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The risk of cardiac events is significantly higher among subjects with mutations at the LQT1 or LQT2 locus than among those with mutations at the LQT3 locus.
|
9753711 |
1998 |
|
cardiac event
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This mutation, Ala561Thr, in the coding sequence of the fifth membrane-spanning domain (S5) of the HERG protein seems to convey a risk of cardiac events in affected family members.
|
8877771 |
1996 |