|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
MALAT1 lncRNA may mediate joint inflammation in obese OA patients..
|
31682073 |
2020 |
|
Brain Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of Malat1 attenuated the inflammatory injury after brain ischemia, whereas overexpression of Malat1 exacerbated ischemic brain inflammation.
|
31431734 |
2020 |
|
Encephalitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of Malat1 attenuated the inflammatory injury after brain ischemia, whereas overexpression of Malat1 exacerbated ischemic brain inflammation.
|
31431734 |
2020 |
|
Kidney Failure, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MALAT1 up-regulation and miR-499 down-regulation might be involved in diabetic nephropathy-related ESRD pathogenesis.
|
30270667 |
2020 |
|
Hypopharyngeal Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cell cycle analysis, Cell Counting Kit-8 assay, Transwell assay, quantitative reverse transcription PCR, and wound-healing assays were performed to evaluate the impact of MALAT1 depletion on laryngeal or hypopharyngeal cancer cell's growth, proliferation, apoptosis, invasion and migration.
|
31792655 |
2020 |
|
Chronic Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MALAT1 up-regulated in inflammatory gingival tissues of chronic periodontitis.
|
31552681 |
2020 |
|
Avascular Necrosis of Femur Head
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
LncRNA-MALAT1 promotes osteogenic differentiation through regulating ATF4 by sponging miR-214: Implication of steroid-induced avascular necrosis of the femoral head.
|
31678133 |
2020 |
|
Pharyngeal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, we developed a MALAT1 silencing model in human laryngeal tumor cells by transfecting MALAT1 small interfering RNA into human laryngeal carcinoma cell line Hep-2 and pharyngeal carcinoma cell line FaDu with Lipofectamine 2000 system.
|
31792655 |
2020 |
|
Differentiated Thyroid Gland Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study indicated that miR-214 inhibited MALAT1 expression by directly binding to the G allele of MALAT1 rs619586 polymorphism, thus inhibiting CTNNB1 expression and promoting cell proliferation in the pathogenesis of DTC.
|
31456244 |
2020 |
|
Hypopharyngeal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MALAT1 was significantly up-regulated in laryngeal and hypopharyngeal carcinoma cells.
|
31792655 |
2020 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we established a mouse DCM model via streptozocin injection as evidenced by cell hypertrophy and cell apoptosis of myocardial tissue, and found that Malat1 expression was upregulated in the myocardium in DCM mice.
|
31353329 |
2020 |
|
Glioblastoma, IDH-Wildtype
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our aim was to clarify the prognostic significance of MALAT1 in IDH1/2 wild-type primary GB tumors.
|
31479414 |
2020 |
|
Chronic kidney disease stage 5
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MALAT1 up-regulation and miR-499 down-regulation might be involved in diabetic nephropathy-related ESRD pathogenesis.
|
30270667 |
2020 |
|
Periodontal inflammation
|
0.010 |
Biomarker
|
disease |
BEFREE |
MALAT1 enhances inflammatory cytokine production through sponging miR-20a and releasing TLR4, indicating a regulatory role of MALAT1 in periodontal inflammation.
|
31552681 |
2020 |
|
Acute pancreatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Reciprocal Feedback Loop of the MALAT1-MicroRNA-194-YAP1 Pathway Regulates Progression of Acute Pancreatitis.
|
31518341 |
2019 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that Malat1 knockdown may present a new target to limit airway remodeling in asthma.
|
31695627 |
2019 |
|
Ataxia Telangiectasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HBO at 2.5 ATA significantly increased MALAT1 expression in HCAECs and HCAECs-derived exosomes.
|
30301563 |
2019 |
|
Nonproliferative diabetic retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, on comparing NPDR with NDR patients, no significant difference was observed regarding the expression levels of miR-20b and miR-17-3p, in contrast, significant elevation of serum HOTAIR and MALAT1 was found in NPDR.
|
30468285 |
2019 |
|
Deglutition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The goal of this study was to compare dysphagia phenotypes in low and high copy number (LCN and HCN) transgenic superoxide dismutase 1 (SOD1) mouse models of ALS to accelerate the discovery of novel and effective treatments for dysphagia and early amyotrophic lateral sclerosis (ALS) diagnosis.
|
31300881 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Exercise Reduces Insulin Resistance in Type 2 Diabetes Mellitus via Mediating the lncRNA MALAT1/MicroRNA-382-3p/Resistin Axis.
|
31479923 |
2019 |
|
Encephalomyelitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of MALAT1 was decreased in the spinal cords of EAE mice as well as in stimulated splenocytes and primary macrophages.
|
30583215 |
2019 |
|
Gonorrhea
|
0.010 |
Biomarker
|
disease |
BEFREE |
Also, MALAT1 was knocked down in a human GC tumor-derived cell line, KGN, to investigate the role of MALAT1 and its molecular mechanism in cell proliferation.
|
30371869 |
2019 |
|
Hepatitis B
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Under the dominant model, smokers with the MALAT1 rs3200401 CT + TT genotype had a higher frequency of hepatitis B virus (HBV) infection (p = 0.034).
|
31500187 |
2019 |
|
leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of long noncoding RNAs MALAT1, antisense noncoding RNA in the INK4 locus (ANRIL), Hox antisense intergenic RNA (HOTAIR), highly up-regulated in liver cancer RNA (HULC), and leukemia-associated non-coding insulin-like growth factor 1 receptor activator RNA 1 (LUNAR1) in tissues from MF was studied using polymerase chain reaction and RNA interference in MF cell line MyLa were used to address this question.
|
31028199 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dysregulation of miR-335-3p, targeted by NEAT1 and MALAT1 long non-coding RNAs, is associated with poor prognosis in childhood acute lymphoblastic leukemia.
|
30639603 |
2019 |