Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, MALAT1 may be an independent predictive factor for OS in patients living with osteosarcoma.
|
31734255 |
2019 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
miR-425-5p decreases LncRNA MALAT1 and TUG1 expressions and suppresses tumorigenesis in osteosarcoma via Wnt/β-catenin signaling pathway.
|
30986552 |
2019 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RESULTS We found that MALAT1 was frequently upregulated in osteosarcoma samples and cell lines and a high level of MALAT1 predicted poor overall survival in osteosarcoma patients.
|
30793707 |
2019 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Additionally, MALAT1 expression was correlated with tumor size, clinical stage and distant metastasis in patients with OS.
|
30365098 |
2019 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MALAT1 knockdown suppressed OS cell growth and metastasis, induced OS cell apoptosis and delayed tumor growth in an OS xenograft model.
|
28560950 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, our research showed promising potential for new treatment strategies based on epigenetic regulation targeting MALAT1, which will not only coordinate with the patient's immune system, but also eliminate OS in conjunction with chemotherapy.
|
29290771 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Meanwhile, we demonstrated that a depression of MALAT1 suppressed proliferation and promoted apoptosis in OS cell line HOS and 143B.
|
30094957 |
2018 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Besides these, CDK9 was predicted as a downstream gene of miR-206, and we observed that MALAT1 can regulate osteosarcoma progress by modulating CDK9 expression via sponging miR-206.
|
30076726 |
2018 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, rescue experiment and luciferase reporter assay results indicated that MALAT1 modulates RET expression by sponging miR-129-5p in osteosarcomas.
|
30481748 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT‑1) has been reported to upregulated and epigenetically regulate the metastasis in osteosarcoma; however, the regulatory mechanisms of MALAT‑1 expression remain unclear.
|
28098894 |
2017 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the gain and loss function assay showed that miR-205 was suppressed by MALAT1 in osteosarcoma and this interaction between miR-205 and MALAT1 has reciprocal effects.
|
29290978 |
2017 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we showed that MALAT1 and HMGB1 were significantly increased in human OS cell lines and knockdown of MALAT1 reduced HMGB1 expression.
|
28346809 |
2017 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Suppression of FOXO1, identified as a regulatory transcriptional factor of MALAT1, was shown to be able to slow down both proliferation and metastases in OS cells, suggesting that targeting FOXO1 can be useful in the therapy of patients with OS.
|
28160461 |
2017 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The functional experiments show that a decreased MALAT1 could remarkably inhibit osteosarcoma cell metastasis and proliferation but induce cell cycle arrest, indicating that MALAT1 functioned as an oncogene in osteosarcoma.
|
28938647 |
2017 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, EZH2 is highly expressed and associated with the 3' end region of lncRNA MALAT1 in osteosarcoma, and this association finally suppressed the expression of E-cadherin.
|
28388584 |
2017 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a lncRNA, has been discovered to be closely related to OS progression and hypoxia responses which are associated with angiogenesis.
|
29209144 |
2017 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrated the clinical prognostic significance and roles of MALAT1 in osteosarcoma, and suggested that MALAT1 may be considered as a prognostic biomarker and therapeutic target for osteosarcoma.
|
27649655 |
2016 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, MALAT1 may promote OS cell growth through inhibition of MIR376A, leading to increased expression of TGFA.
|
27458156 |
2016 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
17β-estradiol regulates cell proliferation, colony formation, migration, invasion and promotes apoptosis by upregulating miR-9 and thus degrades MALAT-1 in osteosarcoma cell MG-63 in an estrogen receptor-independent manner.
|
25592968 |
2015 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of MALAT1 inhibited the proliferation and invasion of human osteosarcoma cell and suppressed its metastasis in vitro and vivo.
|
25431257 |
2015 |