KDR, kinase insert domain receptor, 3791

N. diseases: 623; N. variants: 23
Disease: Central neuroblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.040 Biomarker disease BEFREE Activation of the HGF-mediated MET pathway is involved in escape to selective VEGFR inhibition in neuroblastoma suggesting combined inhibition of MET and VEGFR signaling to reduce secondary resistance and enhanced invasiveness. 27922668 2017
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.040 Biomarker disease BEFREE In this regard, a more promising target to inhibit NB angiogenesis seems to be the VEGF/VEGFR system. 14605672 2003
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.040 AlteredExpression disease BEFREE Further, Flk-1 mRNA was present both in neuroblastoma cells and vascular endothelial cells. 12483647 2002
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.040 AlteredExpression disease BEFREE Recent studies show that vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR, and a series of other angiogenic molecules, are upregulated in advanced but not low stage human neuroblastoma. 11815985 2002