|
Adenoid Cystic Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
There were no significant differences in expression of CK7, p63, CK5/6, AR, Ki-67, and c-KIT (<i>P</i> > .05) among breast, salivary gland, and metastatic AdCCs.
|
31105427 |
2019 |
|
Adenoid Cystic Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MYB and c-KIT (CD117) were negative, thereby strongly arguing against the diagnosis of adenoid cystic carcinoma.
|
27567603 |
2017 |
|
Adenoid Cystic Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In AdCCs, PKC-δ expression was associated with histological grade (P = 0.049), lymphovascular invasion (P = 0.004), perineural invasion (P = 0.002), and KIT positivity (P = 0.002).
|
28561935 |
2017 |
|
Adenoid Cystic Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We included a total of 108 cases comprising 10 benign and 6 malignant sweat gland tumors, and KIT expression was immunohistochemically detected (positive rate): 10 syringomas (0%), 8 poromas (25%), 20 mixed tumors (40%), 21 spiradenomas (43%), 1 cylindroma (0%), 5 hidradenomas (40%), 7 syringocystadenoma papilliferum cases (0%), 1 papillary hidradenoma (100%), 2 tubulopapillary hidradenomas (50%), 8 hidrocystomas (29%), 2 adenoid cystic carcinomas (100%), 5 porocarcinomas (20%), 6 apocrine carcinomas (33%), 10 extramammary Paget diseases (30%), 1 spiradenocarcinoma (100%), and 1 syringocystadenocarcinoma papilliferum (0%).
|
25634571 |
2015 |
|
Adenoid Cystic Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We retrieved 27 cases of 1-4-cm-sized adenoid cystic carcinomas (ACCs) arising from the PG (n = 12) and SMG (n = 15). c-KIT, VEGF-R2, and CD31 staining were quantified by image-based analysis to define the positive expression or tumor-associated vessel areas in two representative sections per case.
|
24456477 |
2014 |
|
Adenoid Cystic Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate that mutations in genes pertaining to the canonical RAS pathway are found in a minority of AdCCs, and that activating KIT mutations are either absent or remarkably rare in these cancers, and unlikely to constitute a driver and therapeutic target for patients with AdCC.
|
23398044 |
2013 |
|
Adenoid Cystic Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Reappraisal of KIT mutation in adenoid cystic carcinomas of the salivary gland.
|
22077630 |
2012 |
|
Adenoid Cystic Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
When only spindle-cell neoplasms were considered (adenoid cystic carcinomas excluded), the specificity of C-Kit increased to 89%.
|
21400668 |
2011 |
|
Adenoid Cystic Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the c-Kit gene disrupt mitogen-activated protein kinase signaling during tumor development in adenoid cystic carcinoma of the salivary glands.
|
20824047 |
2010 |
|
Adenoid Cystic Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of such potential gain-of-function mutations in exon 11, and less frequently in exons 9, 13 and 17, suggests that KIT may be involved in the pathogenesis of adenoid cystic carcinoma of salivary glands.
|
19617878 |
2009 |
|
Adenoid Cystic Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Differential KIT expression in histological subtypes of adenoid cystic carcinoma (ACC) of the salivary gland.
|
16054424 |
2005 |
|
Adenoid Cystic Carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
c-kit expression in adenoid cystic carcinoma of the breast.
|
15370139 |
2004 |
|
Adenoid Cystic Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma.
|
10530560 |
1999 |