Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In glioblastomas (n = 45), amplification of EGFR [18 (40%)], PDGFRA [3 (7%)], KIT [2 (4%)], MET [1 (2%)], and AKT1 [1 (2%)] was detected.
|
31000415 |
2019 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
LTS GB showed frequent chromosomal gains in 4q12 (platelet derived growth factor receptor alpha and KIT) and 12q14.1 (cyclin-dependent kinase 4), and deletion in 19q13.33 (BAX, branched chain amino-acid transaminase 2, and cluster of differentiation 33).
|
27932423 |
2017 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We find evidence of regional mutational heterogeneity in multiple tumors, including mutations in TP53 and RB1 in an anaplastic oligodendroglioma and amplifications in PDGFRA and KIT in two glioblastomas (GBMs).
|
25608559 |
2014 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A younger age at diagnosis and better clinical outcome in glioblastoma patients is only seen when PDGFRA and KIT are co-amplified.
|
23990986 |
2013 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
No significant difference was observed in the frequency of amplification of these genes in primary and secondary glioblastomas or in glioblastomas with and without IDH1 mutations, suggesting that amplification of PDGFRA, KIT and KDR may be implicated in the pathogenesis of a small fraction of both subtypes of glioblastoma.
|
21382095 |
2011 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
KIT receptor tyrosine kinase is expressed in tumor endothelial cells of adult glioblastomas, but its expression in pediatric brain tumor endothelial cells is unknown.
|
20030644 |
2010 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It is concluded that marked KIT and phosphorylated KIT expression is frequently present in the endothelial cells of glioblastomas, which are known to harbour florid microvascular proliferation with characteristic morphological features.
|
17294421 |
2007 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, CISH and/or qRT-PCR analysis revealed the presence of KIT gene amplification in 6 glioblastomas and 2 anaplastic oligoastrocytomas, corresponding to 33% (8/24) of CD117 positive cases.
|
17726262 |
2007 |
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Glioblastomas with KIT, PDGFR or VEGFR2 amplification were associated with similar outcome to other glioblastomas.
|
16021678 |
2005 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Normal astrocytes were positive for IL-1RI, p75TNFR, p55TNFR, IFN-alpha/beta R, IFN-gamma R, M-CSFR, and SCFR, showing a similarity to glioblastoma cells.
|
7514661 |
1994 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, GA-17 reacted with c-kit protein expressed on the membrane of A172 human glioblastoma cells.
|
1370880 |
1992 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In view of similarities noted between the cell surface antigen identified by YB5.B8 and the c-kit protein product, we performed experiments to determine whether they are identical. c-kit RNA expression in the cell lines HEL (human erythroleukemia) and A172 (glioblastoma) was shown to parallel the expression of the YB5.B8 epitope in these lines as measured by flow cytometry.
|
1708291 |
1991 |