|
Acute monocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CXCR4+ patients in the t(8;21) AML without KIT mutation group had a significantly worse 3-year OS than CXCR4- patients (n = 44; 76.1% vs. 100.0%, P = 0.01).
|
27135782 |
2016 |
|
Acute monocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome.
|
27391574 |
2016 |
|
Acute monocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The poor prognostic impact of c-KIT mutation in t(8;21) AML patients only applies in a specific patient subgroup without WT1 mutations.
|
25932436 |
2015 |
|
Acute monocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DNA microarray and quantitative polymerase chain reaction screening for differentially expressed genes between KD clones and non-KD control cells revealed significant up-regulation of the tyrosine kinase receptor, KIT, hyperactive mutations of which are often found in AML.
|
25928165 |
2015 |
|
Acute monocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, with regard to c-KIT mutation, CBF-AML is a heterogeneous disease. c-KIT mutations have a strong adverse effect on the relapse and survival of adult t(8;21) AML patients.
|
25449688 |
2014 |
|
Acute monocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
New data on incidence of c-KIT mutations in various AML subtypes as well as new variations of c-KIT mutations in the exon 8 are presented.
|
23511494 |
2013 |
|
Acute monocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
AML with isolated trisomy 4 is rare and associated with high bone marrow blast counts and an intermediate to poor prognosis.KIT mutations are uncommon.
|
22338050 |
2012 |
|
Acute monocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation.
|
22109829 |
2012 |
|
Acute monocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML.
|
20056794 |
2010 |
|
Acute monocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
FLT3 and KIT mutated pediatric acute myeloid leukemia (AML) samples are sensitive in vitro to the tyrosine kinase inhibitor SU11657.
|
20435347 |
2010 |
|
Acute monocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival.
|
16254134 |
2006 |
|
Acute monocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We suggest that patients with core-binding factor AML should be screened for mutKIT at diagnosis for both prognostic and therapeutic purposes, given that activated KIT potentially can be targeted with novel tyrosine kinase inhibitors.
|
16921041 |
2006 |
|
Acute monocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lack of KIT or FMS internal tandem duplications but co-expression with ligands in AML.
|
14654075 |
2004 |
|
Acute monocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of exons 2, 8, 10, 11, and 17 of the c-Kit receptor did not reveal structural alterations as previously described in a subset of AML cases.
|
12480706 |
2003 |
|
Acute monocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD34 and CD117 are overexpressed in AML and may be valuable to detect minimal residual disease.
|
12008077 |
2002 |