KLRB1, killer cell lectin like receptor B1, 3820

N. diseases: 71; N. variants: 2
Disease: Hepatitis C ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.020 Biomarker disease BEFREE Compared to controls, virally infected pts displayed significantly lower circulating Vα7.2+CD161++CD8+ MAIT cells (<i>p</i> = 0.001), yet expressed higher perforin (<i>p</i> = 0.004) and granzyme B (<i>p</i> = 0.002) on CD8+ MAIT cells.Upon <i>E. coli</i> stimulation, the residual MAIT cells are less functional particularly those from HIV+/HCV+ patients. 31555223 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.020 AlteredExpression disease LHGDN We found that CD161 was significantly expressed on HCV-specific cells (median 16.8%) but not on CD8+ T cells specific for human immunodeficiency virus (3.3%), cytomegalovirus (3.4%), or influenza (3.4%). 18219672 2008
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.020 AlteredExpression disease BEFREE CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation. 18219672 2008