KNG1, kininogen 1, 3827

N. diseases: 279; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE Bradykinin receptor activation is involved in inflammatory reactions, but has never been investigated in fracture pain. 31640792 2019
CUI: C0010200
Disease: Coughing
Coughing
0.380 Biomarker phenotype BEFREE Our findings show that central BK administration sensitizes cough and enhances airway obstruction via a B<sub>2</sub> receptor/TRPV1 and/or TRPA1 channels which are coupled via metabolites of COX and/or 12-LOX enzymes. 31170972 2019
CUI: C0002792
Disease: anaphylaxis
anaphylaxis
0.360 Biomarker phenotype BEFREE Angioedema can occur in isolation, accompanied by urticaria, or as a feature of anaphylaxis in mast cell-mediated disorders, bradykinin-mediated disorders, as well as in others with unknown mechanisms, such as infections, rare disorders, or idiopathic angioedema. 30679975 2019
CUI: C2931758
Disease: Acquired angioedema
Acquired angioedema
0.340 Biomarker disease BEFREE Acquired angioedema due to C1-inhibitor (C1INH) deficiency (AAE) is caused by secondary C1INH deficiency leading to bradykinin-mediated angioedema episodes. 31397881 2019
CUI: C0019193
Disease: Hepatitis, Toxic
Hepatitis, Toxic
0.300 Biomarker disease CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357 2019
CUI: C0028796
Disease: Dermatitis, Occupational
Dermatitis, Occupational
0.300 Biomarker disease CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357 2019
CUI: C0086457
Disease: Industrial Dermatosis
Industrial Dermatosis
0.300 Biomarker disease CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357 2019
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.300 Biomarker phenotype CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357 2019
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.300 Biomarker disease CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357 2019
CUI: C3658290
Disease: Drug-Induced Acute Liver Injury
Drug-Induced Acute Liver Injury
0.300 Biomarker disease CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357 2019
Chemical and Drug Induced Liver Injury
0.300 Biomarker disease CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357 2019
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity
0.300 Biomarker disease CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357 2019
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.120 Biomarker phenotype BEFREE For example, the hazard ratio of VTE per standard deviation higher HK concentration was 0.88 (95% confidence interval = 0.81, 0.97), after adjustment for several VTE risk factors. 30780167 2019
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism
0.120 GeneticVariation phenotype GWASCAT Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism. 31420334 2019
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.100 Biomarker disease BEFREE Moreover, while the pathogenic AD peptide β-amyloid (Aβ)42 cleaves HK and induces a dramatic increase in bradykinin production, our HK antibody blocked these events from occurring. 31659032 2019
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.100 Biomarker disease BEFREE In particular, we explored the involvement in the AD of Thyrotropin-Releasing Hormone (TRH), Cocaine- and Amphetamine-Regulated Transcript (CART), Cholecystokinin (CCK), bradykinin and chromogranin/secretogranin family, discussing their potential role as a biomarker or therapeutic target, leaving the dissertation of other neuropeptides to previous reviews. 31456515 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Bradykinin is produced in response to inflammation, trauma, burns, shock, allergy and some cardiovascular diseases. 30466897 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE We observed no significant relation between HK or PK and cardiovascular disease or heart failure, before and after adjusting for several potential confounding variables. 31473403 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 AlteredExpression group BEFREE As emerged from the literature, high levels of KNG1 and low amounts of A1AT seem to be related with a highest probability to develop CVD. 31338581 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.100 Biomarker disease BEFREE In the prospective population-based Atherosclerosis Risk in Communities(ARIC) Study, we used Cox proportional hazards regression models to investigate the association in 4195 middle-aged adults of plasma HK and PK concentrations in 1993-95 (linearly and in quartiles) with incident coronary heart disease, ischemic stroke, and heart failure through 2016. 31473403 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.080 Biomarker disease BEFREE In the prospective population-based Atherosclerosis Risk in Communities(ARIC) Study, we used Cox proportional hazards regression models to investigate the association in 4195 middle-aged adults of plasma HK and PK concentrations in 1993-95 (linearly and in quartiles) with incident coronary heart disease, ischemic stroke, and heart failure through 2016. 31473403 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 AlteredExpression phenotype BEFREE Furthermore, it was confirmed that overexpression of bradykinin B2 receptor (B2R) facilitated the proliferation, migration, and invasion of BK‑treated CC cells, while knockdown of B2R had the opposite effect. 31638249 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.060 Biomarker group BEFREE A recent study indicated that BK played an important role in the occurrence and progression of cancer. 31059006 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.060 Biomarker disease BEFREE In the prospective population-based Atherosclerosis Risk in Communities(ARIC) Study, we used Cox proportional hazards regression models to investigate the association in 4195 middle-aged adults of plasma HK and PK concentrations in 1993-95 (linearly and in quartiles) with incident coronary heart disease, ischemic stroke, and heart failure through 2016. 31473403 2019
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.060 Biomarker group BEFREE The markers related to NET (DNA-histone complex) and kallikrein-kinin system (high-molecular-weight kininogen, prekallikrein, bradykinin) and factor XIIa were measured in 253 patients with diabetes. 31426112 2019