KNG1, kininogen 1, 3827

N. diseases: 279; N. variants: 24
Disease: Asthma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE Bradykinin activates epithelial/endothelial and immune cells, neurons and mesenchymal cells (such as fibroblasts, myofibroblasts and smooth muscle cells), which are implicated in the development of airway chronic inflammation, responsiveness and remodelling (a major feature of severe asthma). 29548973 2018
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE Moreover, we show that prophylactic administration of TRPV1 (AMG9810) and LPA (BrP-LPA) receptor antagonists prevents bradykinin-induced asthmatic bronchoconstriction and, if administered following allergen exposure, reduces the associated respiratory distress. 30279412 2018
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE In vitro, microvesicles from patients with asthma impaired the relaxation to bradykinin and contraction to acetylcholine, whereas microparticles from healthy subjects did not. 28444548 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE Bradykinin B2 receptor expression in the bronchial mucosa of allergic asthmatics: the role of NF-kB. 26588817 2016
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE When we compared results in asthmatic and nonasthmatic muscle cells, both trypsin and bradykinin induced less PGE2 from asthmatic ASM cells, and bradykinin induced significantly less COX-2 mRNA in asthmatic cells. 12754192 2003
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE Increased levels of bradykinin and IL-8 have been detected within the airways of individuals with active symptoms of allergic rhinitis and asthma. 12532104 2003
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE Since BE1-2G has previously been shown to lead to a higher transcription rate of the B2 receptor, this result warrants further investigation of the role of bradykinin in conferring susceptibility to pediatric asthma. 11517947 2001
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE Angiotensin-converting enzyme (ACE) is expressed at high levels in the lungs and plays a role in the metabolism of angiotensin II, bradykinin, and substance P, all of which are potentially involved in the pathogenesis of asthma. 11030378 2000
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE Angiotensin-converting enzyme (ACE) inactivates bradykinin, substance P and neurokinin A, which are believed to play important roles in the pathogenesis of asthma, especially in neurogenic inflammation. 10197222 1998
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE Because ACE is heavily expressed in the lungs and plays a key role in the metabolism of angiotensin II and bradykinin, which are potentially involved in the pathogenesis of asthma, we tested the hypothesis of an association between the polymorphism of the ACE gene and asthma. 9003211 1997