|
Asthma
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Two polymorphisms in arginase 2 (rs17249437 and rs3742879) were associated with asthma and with more severe airway obstruction.
|
20124949 |
2010 |
|
Asthma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
To determine the relationships of iNOS expression/activation and arginase 2 expression with asthma severity, FeNO, nitrotyrosine (NT) and eosinophilic inflammation.
|
22092728 |
2012 |
|
Asthma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Carrying 2 copies of minor alleles for either of 2 highly associated ARG2 SNPs was associated with a statistically significant increased relative risk (RR) of asthma (1.5, 95% CI = 1.1-2.1 for arg2s1; RR = 1.6, 95% CI = 1.1-2.3 for arg2s2).
|
16387594 |
2006 |
|
Asthma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.
|
12813015 |
2003 |
|
Asthma
|
0.390 |
Biomarker
|
disease |
BEFREE |
DNA methylation in ARG1 and ARG2 is associated with FeNO in children with asthma and suggests a possible role for epigenetic regulation of nitric oxide production.
|
21512169 |
2011 |
|
Asthma
|
0.390 |
Biomarker
|
disease |
CTD_human |
Compared with the most common haplotype within each locus, 1 ARG1 haplotype was associated with reduced risk (odds ratio [OR] per haplotype copy, 0.55; 95% CI, 0.36-0.84), and 1 ARG2 haplotype was associated with increased risk (OR per haplotype copy, 1.35; 95% CI, 1.04-1.76) of asthma.
|
19281908 |
2009 |
|
Asthma
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Compared with the most common haplotype within each locus, 1 ARG1 haplotype was associated with reduced risk (odds ratio [OR] per haplotype copy, 0.55; 95% CI, 0.36-0.84), and 1 ARG2 haplotype was associated with increased risk (OR per haplotype copy, 1.35; 95% CI, 1.04-1.76) of asthma.
|
19281908 |
2009 |
|
Asthma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
The elevated arginase II activity and expression may be a mechanism underlying adverse effects induced by PM exposure in asthma patients.
|
22712848 |
2012 |
|
Asthma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Genes related to metabolism of basic amino acids, specifically the cationic amino acid transporter 2, arginase I, and arginase II, were particularly prominent among the asthma signature genes.
|
12813022 |
2003 |
|
Asthma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Low FENO asthmatics had near normal iNOS and ARG2 expression (both P > 0.05), and significantly higher PC20 (P < 0.001) as compared to high FENO asthmatics.
|
28797075 |
2017 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
CTD_human |
In contrast to prostate cancer, ARG2 expression was rarely demonstrated in PDC cells by immunohistochemistry, and instead ARG2 was characteristically expressed in α-smooth muscle actin-positive cancer-associated fibroblasts (CAFs), especially those located within and around necrotic areas in PDC.
|
23424623 |
2013 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
BEFREE |
Arginase 2, inducible- and endothelial-nitric-oxide synthase (iNOS and eNOS), indoleamine 2,3-dioxygenase (IDO) and TGF-beta, might impair immune functions in prostate cancer (PCA) patients.
|
18619832 |
2008 |
|
Malignant neoplasm of prostate
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
In this report, we demonstrate that both ARG1 and ARG2 are expressed by hormone-sensitive (HS) and hormone-refractory (HR) PCa cell lines, with the LNCaP cells having the highest arginase activity.
|
20711410 |
2010 |
|
Carcinoma, Pancreatic Ductal
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Here we studied the expression of ARG2 in pancreatic ductal carcinoma (PDC) tissue clinicopathologically by examining over 200 cases of PDC.
|
23424623 |
2013 |
|
Carcinoma, Pancreatic Ductal
|
0.310 |
Biomarker
|
disease |
CTD_human |
Here we studied the expression of ARG2 in pancreatic ductal carcinoma (PDC) tissue clinicopathologically by examining over 200 cases of PDC.
|
23424623 |
2013 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Oral administration of orthovanadate and Trigonella foenum graecum seed power restore the activities of mitochondrial enzymes in tissues of alloxan-induced diabetic rats.
|
12841630 |
2003 |
|
Kidney Failure, Chronic
|
0.200 |
Biomarker
|
disease |
RGD |
Effect of chronic renal failure on arginase and argininosuccinate synthetase expression.
|
16809898 |
2006 |
|
Liver Cirrhosis, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Induction of arginase II in livers of bile duct-ligated rats.
|
11931836 |
2002 |
|
Sepsis
|
0.200 |
Biomarker
|
disease |
RGD |
Differential expression of arginase and iNOS in the lung in sepsis.
|
9635249 |
1998 |
|
Chronic kidney disease stage 5
|
0.200 |
Biomarker
|
disease |
RGD |
Effect of chronic renal failure on arginase and argininosuccinate synthetase expression.
|
16809898 |
2006 |
|
Acute kidney injury
|
0.200 |
Biomarker
|
disease |
RGD |
L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats.
|
12371970 |
2002 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
Given that arginase-II (Arg-II) exerts some of its biological functions through crosstalk with signal transduction pathways, and that p38 mitogen-activated protein kinase (p38mapk) is involved in eNOS-uncoupling, we investigated here whether p38mapk is involved in Arg-II-mediated eNOS-uncoupling in a high fat diet (HFD)-induced obesity mouse model.
|
25034973 |
2014 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
We conclude that hepatocyte Arg2 is a critical effector of the hepatic glucose fasting response and define a therapeutic target to mitigate the complications of obesity and non-alcoholic fatty liver disease.
|
30962478 |
2019 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice.
|
30909461 |
2019 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here the authors show that obesity induces the expression of the mitochondrial form of arginase ARG2 in PDA and that ARG2 silencing or loss results in ammonia accumulation and suppression of obesity-driven PDA tumor growth.
|
28808255 |
2017 |