ARG2, arginase 2, 384

N. diseases: 103; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.040 AlteredExpression disease BEFREE When compared to normal human cavernosal tissue, diabetic corpus cavernosum from humans with erectile dysfunction had higher levels of arginase II protein, gene expression, and enzyme activity. 11350073 2001
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.040 Biomarker disease BEFREE Given that human arginase II appears to play a role in regulating l-arginine bioavailability to NO synthase in human penile corpus cavernosum smooth muscle, the inhibition of human arginase II is a potential new strategy for the treatment of erectile dysfunction [Kim, N. N., Cox, J. D., Baggio, R. F., Emig, F. A., Mistry, S., Harper, S. L., Speicher, D. W., Morris, S. M., Ash, D. E., Traish, A. M., and Christianson, D. W. (2001) Biochemistry 40, 2678-2688]. 12859189 2003
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.040 Biomarker disease BEFREE Increased Arginase 2 concentrations were found in clinical ED and are associated with increased risk for ED. 26537638 2015
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.040 AlteredExpression disease BEFREE Serum Arginase II level can be a novel indicator for erectile dysfunction in patients with vasculogenic erectile dysfunction: a comparative study. 29956132 2018
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.030 GeneticVariation disease BEFREE Polymorphisms in arginase 1 and arginase 2 genes have been associated with childhood asthma and FEV1 reversibility to beta2 agonists. 20124949 2010
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.030 GeneticVariation disease BEFREE To examine the association between genetic variation in ARG1 and ARG2 and childhood asthma and atopy risk. 16387594 2006
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.030 GeneticVariation disease BEFREE ARG1 and ARG2 loci are associated with childhood asthma. 19281908 2009
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.020 AlteredExpression disease BEFREE Deficient arginase II expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice. 29574762 2018
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.020 AlteredExpression disease BEFREE Increased expression of A2 was observed in WT retinas in response to EAE induction. 31280447 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.020 AlteredExpression disease BEFREE Moreover, higher levels of ARG2 expression tended to be associated with poorer survival in GBM patient by analyzing data from TCGA. 27363017 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.020 AlteredExpression disease BEFREE Re-expression of arginase-2 markedly reversed the inhibitory properties of microRNA-613 in glioblastoma cells. 28718378 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.020 Biomarker disease BEFREE As immune cell activity can be determined by flux through metabolic pathways, the mRNA expression of l-tryptophan- and l-arginine-catabolising enzymes, indoleamine 2,3-dioxygenase (IDO) 1 and IDO2 and arginase (ARG) 1 and ARG2, respectively, was compared between peripheral blood mononuclear cells (PBMCs) from healthy controls, and patients with CIS and definite MS. As one measure of cell function, cytokine mRNA levels were analysed directly <i>ex vivo</i> and in cells after culture for 4 h in the absence of regulatory factors in autologous serum. 30128151 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.020 Biomarker disease BEFREE In conclusion, our studies establish EAE as an excellent model to study MS-mediated retinal neuronal damage and suggest the potential value of targeting A2 as a therapy to prevent MS-mediated retinal neuronal injury. 31280447 2019
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.020 AlteredExpression disease BEFREE Increased ARG2 expression was found in patients with CRS without nasal polyposis (FR 3.14 ± 1.16 vs. 1.31 ± 0.21, <i>p</i> = 0.0175), in non-allergic CRS (FR 2.55 ± 0.52 vs. 1.31 ± 0.21, <i>p</i> = 0.005), and non-asthmatic CRS (FR 2.42 ± 0.57 vs. 1.31 ± 0.21, <i>p</i> = 0.028). 31683763 2019
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.020 Biomarker disease BEFREE Increased arginase-2 activities in chronic rhinosinusitis without nasal polyps patients were associated with significantly lower levels of nasal fractional exhaled nitric oxide. 26487482 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.020 AlteredExpression disease BEFREE High arginase II expression correlates with poor survival for patients with neuroblastoma. 26054597 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.020 AlteredExpression disease BEFREE IL1β and TNFα established a feedback loop to upregulate ARG2 expression via p38 and extracellular regulated kinases 1/2 (ERK1/2) signaling in neuroblastoma and neural crest-derived cells. 30545920 2019
CUI: C0149516
Disease: Chronic sinusitis
Chronic sinusitis 		0.020 Biomarker disease BEFREE Increased arginase-2 activities in chronic rhinosinusitis without nasal polyps patients were associated with significantly lower levels of nasal fractional exhaled nitric oxide. 26487482 2015
CUI: C0149516
Disease: Chronic sinusitis
Chronic sinusitis 		0.020 AlteredExpression disease BEFREE The levels of ARG2 were significantly higher in patients with chronic rhinosinusitis compared to the control group (fold regulation (FR) 2.22 ± 0.42 vs. 1.31 ± 0.21, <i>p</i> = 0.016). 31683763 2019
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.020 AlteredExpression disease BEFREE High levels of endogenous arginase 2 (ARG2) have been previously reported in human lung cancers. 30808864 2019
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.020 Biomarker disease BEFREE However, immune suppression mediated by ARG2-expressing cancer cells in lung cancer has not been observed. 23424623 2013
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.020 Biomarker disease BEFREE Arginase 2, inducible- and endothelial-nitric-oxide synthase (iNOS and eNOS), indoleamine 2,3-dioxygenase (IDO) and TGF-beta, might impair immune functions in prostate cancer (PCA) patients. 18619832 2008
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.020 AlteredExpression disease BEFREE In this report, we demonstrate that both ARG1 and ARG2 are expressed by hormone-sensitive (HS) and hormone-refractory (HR) PCa cell lines, with the LNCaP cells having the highest arginase activity. 20711410 2010
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.020 AlteredExpression disease BEFREE IL1β and TNFα established a feedback loop to upregulate ARG2 expression via p38 and extracellular regulated kinases 1/2 (ERK1/2) signaling in neuroblastoma and neural crest-derived cells. 30545920 2019
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.020 AlteredExpression disease BEFREE High arginase II expression correlates with poor survival for patients with neuroblastoma. 26054597 2015