|
Asthma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Low FENO asthmatics had near normal iNOS and ARG2 expression (both P > 0.05), and significantly higher PC20 (P < 0.001) as compared to high FENO asthmatics.
|
28797075 |
2017 |
|
Asthma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
To determine the relationships of iNOS expression/activation and arginase 2 expression with asthma severity, FeNO, nitrotyrosine (NT) and eosinophilic inflammation.
|
22092728 |
2012 |
|
Asthma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
The elevated arginase II activity and expression may be a mechanism underlying adverse effects induced by PM exposure in asthma patients.
|
22712848 |
2012 |
|
Asthma
|
0.390 |
Biomarker
|
disease |
BEFREE |
DNA methylation in ARG1 and ARG2 is associated with FeNO in children with asthma and suggests a possible role for epigenetic regulation of nitric oxide production.
|
21512169 |
2011 |
|
Asthma
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Two polymorphisms in arginase 2 (rs17249437 and rs3742879) were associated with asthma and with more severe airway obstruction.
|
20124949 |
2010 |
|
Asthma
|
0.390 |
Biomarker
|
disease |
CTD_human |
Compared with the most common haplotype within each locus, 1 ARG1 haplotype was associated with reduced risk (odds ratio [OR] per haplotype copy, 0.55; 95% CI, 0.36-0.84), and 1 ARG2 haplotype was associated with increased risk (OR per haplotype copy, 1.35; 95% CI, 1.04-1.76) of asthma.
|
19281908 |
2009 |
|
Asthma
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Compared with the most common haplotype within each locus, 1 ARG1 haplotype was associated with reduced risk (odds ratio [OR] per haplotype copy, 0.55; 95% CI, 0.36-0.84), and 1 ARG2 haplotype was associated with increased risk (OR per haplotype copy, 1.35; 95% CI, 1.04-1.76) of asthma.
|
19281908 |
2009 |
|
Asthma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Carrying 2 copies of minor alleles for either of 2 highly associated ARG2 SNPs was associated with a statistically significant increased relative risk (RR) of asthma (1.5, 95% CI = 1.1-2.1 for arg2s1; RR = 1.6, 95% CI = 1.1-2.3 for arg2s2).
|
16387594 |
2006 |
|
Asthma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.
|
12813015 |
2003 |
|
Asthma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Genes related to metabolism of basic amino acids, specifically the cationic amino acid transporter 2, arginase I, and arginase II, were particularly prominent among the asthma signature genes.
|
12813022 |
2003 |