|
Adenomatous Polyposis Coli
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of miR31 and miR92a were evaluated by real-time PCR using TaqMan probes; in addition, two oncogenes (KRAS and c-MYC) and two tumor suppressors (AMP-activated protein kinase [AMPK] and adenomatous tumors of polyposis coli [APC]) were quantified to validate the biological effects; normalization of expression levels were carried out by 2<sup>-ΔΔCt</sup>.Results were analyzed by one-way ANOVA.
|
31441682 |
2020 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Collectively, our study highlights the importance of REG4 in promoting CSCs properties induced by KRAS mutation, and provides a new therapeutic strategy for CRC harboring both APC and KRAS mutations.
|
31605540 |
2020 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
The final model of the disease was generated by the cross of the two parental colonies and viable APC <sup>f/f</sup> KRAS <sup>+/f</sup> CDX2-Cre-ER<sup>T2</sup> (KPC: APC) were genotyped and characterized.
|
31766149 |
2019 |
|
Adenomatous Polyposis Coli
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Colorectal cancer (CRC) is categorized by alteration of vital pathways such as β-catenin (CTNNB1) mutations, WNT signaling activation, tumor protein 53 (TP53) inactivation, BRAF, Adenomatous polyposis coli (APC) inactivation, KRAS, dysregulation of epithelial to mesenchymal transition (EMT) genes, MYC amplification, etc.
|
31699039 |
2019 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrated that mutational rates for APC and KRAS differ between colitic cancer and sporadic CRC.
|
28871001 |
2018 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
KYA1797K suppressed the growth of tumor xenografts induced by CRC cells as well as tumor organoids derived from CRC patients having both APC and KRAS mutations.
|
30459318 |
2018 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The mutation rates of Kirsten rat sarcoma viral oncogene homolog (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA), and B-Raf proto-oncogene serine/threonine kinase (BRAF) were higher in proximal tumors, and the mutation rates of adenomatous polyposis coli (APC), tumor protein 53 (TP53), and neuroblastoma RAS viral oncogene homolog (NRAS) were higher in distal tumors.
|
28513830 |
2017 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
By using both in vitro and in vivo studies, we showed that KYA1797K suppressed the growth of CRCs harboring APC and KRAS mutations through destabilization of β-catenin and Ras.
|
27470214 |
2016 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated familial adenomatous polyposis (FAP), through quantitative methylation analysis of 127 samples (16 cancers, 96 adenomas, and 15 benign mucosa from 14 patients with FAP) using six Group-1 and 14 Group-2 methylation markers, APC, BRAF, and KRAS mutation analysis, and CTNNB1 and TP53 immunohistochemical analysis.
|
27563825 |
2016 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
The authors identified recurrent mutations in tumor protein p53 (TP53), KRAS, catenin (cadherin-associated protein) β-1 (CTNNB1), AT-rich interactive domain 2 (ARID2), adenomatous polyposis coli (APC), erb-b2 receptor tyrosine kinase 2 (ERBB2), ARID1A, cadherin-related family member 1 (CDHR1), NRAS, Bcl-2-related ovarian killer (BOK), radial spoke head 14 homolog (chlamydomonas) (RTDR1), cell division cycle 27 (CDC27), catalytic subunit of phosphoinositide-3-kinase (PIK3CA), and SMAD family member 4 (SMAD4).
|
26998897 |
2016 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutational statuses of GNAS and KRAS, which are frequently mutated in sporadic PGAs, as well as those of APC, were examined in PGAs, FAs and FGPs in patients with FAP using Sanger sequencing.
|
25832318 |
2015 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A genome analysis revealed that low-MC had a considerably larger number of mutations than high-MC, and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations and adenomatous polyposis coli mutations were particularly frequently found in low-MC.
|
26488212 |
2015 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both components shared somatic mutations in Adenomatous polyposis coli (APC), Kirsten rat sarcoma viral oncogene homolog (KRAS), B-cell CLL/lymphoma 9 (BCL9) and Forkhead Box P1 (FOXP1) genes.
|
25275049 |
2014 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of the CSC markers CD44, CD133, and CD166 was induced in intestinal tumors from APC (Min/+)/K-Ras (LA2)mice, but not K-Ras (LA2) mice, indicating that APC mutation is required for CSC activation by oncogenic K-Ras mutation.
|
24491301 |
2014 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutated MUTYH-associated-polyposis carcinomas showed KRAS c.34G>T transversions, prevalently occurring with BRAFV600E; none of the classical/attenuated familial polyposis carcinomas displayed these alterations.
|
23599153 |
2013 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations in known driver genes [e.g., adenomatous polyposis coli (APC), KRAS, or PIK3CA] found in the primary tumor and metastasis were also detected in corresponding CTCs.
|
23471846 |
2013 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Colorectal cancer often follows a genetic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and activation of β-catenin are followed by mutations in K-Ras, PIK3CA and TP53, as the tumour emerges and progresses.
|
23034650 |
2012 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas.
|
20196079 |
2010 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results indicated that the LOH of APC and p53 mutation has already occurred by the Dukes' A lake 'suppressor pathway' but not the KRAS mutation in MSI-L CRCs.
|
19147861 |
2009 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
Individual crypt adenomatous polyposis coli (APC), p53, K-RAS, and 17p loss of heterozygosity mutation burden was established using polymerase chain reaction and sequencing analysis.
|
19103203 |
2009 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similar to colorectal adenomas, they harbor APC and KRAS mutations; but BRAF mutations, p53 alterations, and DNA mismatch repair abnormalities are rare.
|
18670349 |
2008 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no relationship of hypermethylation of any gene, including MGMT, with G-to-A or C-to-T transitions in KRAS or P53, although APC hypermethylation was associated with P53 mutation (P < 0.0002).
|
18451217 |
2008 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate baseline fat intake and the risk of colon and rectal tumors lacking MLH1 (mutL homolog 1, colon cancer, nonpolyposis type 2) repair gene expression and harboring mutations in the APC (adenomatous polyposis coli) tumor suppressor gene and in the KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) oncogene.
|
17636402 |
2007 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To design a practical approach for a molecular diagnosis of micrometastasis, we applied direct DNA sequencing to screen 48 early stage colorectal carcinomas for the most frequent mutations of the KRAS, P53, and APC tumor genes.
|
17525678 |
2007 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although chromosomal instability characterizes the majority of human colorectal cancers, the contribution of genes such as adenomatous polyposis coli (APC), KRAS, and p53 to this form of genetic instability is still under debate.
|
17200209 |
2007 |