Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To evaluate effect modification, the association between tertiles (T) of xanthophyll intake and AMD was stratified by complement factor H (CFH) rs1061170 and age-related maculopathy susceptibility 2 (ARMS2) rs10490924 genotypes, as well as by median cutpoints of HDL biomarkers.
|
28332910 |
2017 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in two genes were associated with AMD (ARMS2: OR = 2.28, CI 1.48-3.51; P = 0.005; CFH: OR = 2.03, CI 1.35-3.06; P = 0.010).
|
27974306 |
2017 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of combined cigarette smoking and ARMS2/LOC387715 A69S polymorphisms with age-related macular degeneration: A meta-analysis.
|
28095100 |
2017 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we confirm that ARMS2, HTRA1 and CFH variants are associated with neovascular AMD in the Thai population.
|
28703135 |
2017 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
The ARMS2 protein was localized in human genotyped retinal sections and in purified monocytes derived from AMD patients without the ARMS2 risk variant by LSM.
|
28086806 |
2017 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to investigate age-related maculopathy susceptibility protein 2 (ARMS2) gene sequences among Turkish patients with exudative AMD.
|
28128407 |
2017 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Using a panel of 8854 SNPs associated with AAMD at p-values ≤5.0E-7 from a cohort of >30,000 elderly people, we identified SNPs in miRNA target-encoding constituents of: (1) regulator of complement activation (RCA) genes (rs390679, CFHR1, p≤2.14E-214 ; rs12140421, CFHR3, p≤4.63E-29); (2) genes of major histocompatibility complex (MHC) loci (rs4151672, CFB, p≤8.91E-41 ; rs115404146, HLA-C, p≤6.32E-12 ; rs1055821, HLA-B, p≤1.93E-9 ; rs1063355, HLA-DQB1, p≤6.82E-14); and (3) genes of the 10q26 AAMD locus (rs1045216, PLEKHA1, p≤4.17E-142 ; rs2672603, ARMS2, p≤7.14E-46).
|
28343170 |
2017 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the association between the genotype of ARMS2 rs10490924 polymorphism and IVR treatment responsiveness in patients with neovascular AMD.
|
28002601 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The association with risk alleles of the age-related maculopathy susceptibility 2 (ARMS2) gene was significantly stronger in sporadic AMD patients compared to familial cases (p = 0.017 for all AMD stages and p = 0.003 for advanced AMD, respectively).
|
27258093 |
2016 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
To investigate associations of very early age-related macular degeneration (AMD) with daily intake of vitamin A, beta-carotene, vitamin E, vitamin C, zinc and copper and interactions with AMD-associated polymorphisms in complement factor H (CFHY402H) and ARMS2/LOC387715.
|
27502478 |
2016 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) associated with the CFH, ARMS2, C3, LIPC, CFB, and C2 genes are associated with age-related macular degeneration (AMD); however, the association of these SNPs with angiographic features of neovascular AMD has been inconsistent in previous studies, and to date, no studies have addressed their association with features on optical coherence tomography.
|
27099955 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Two loci in particular, including genes of the complement cascade on chromosome 1 and the ARMS2/HTRA1 genes on chromosome 10, have been shown to convey significantly increased susceptibility to developing AMD.
|
26020418 |
2016 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Age, race/ethnicity, current smoking, hyperopia, and AMD-susceptibility genotypes Complement Factor H (CFH) RS1061170 and Age Related Maculopathy Susceptibility 2 (ARMS2) RS3793917 were independently associated with incident early AMD in multivariable models for the combined sample.
|
26896123 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this meta-analysis, we pooled the results of the available association studies between combined ARMS2/LOC387715A69S-CFHY402H genotypes and AMD to estimate the possible synergistic or multiplicative effects.
|
27269047 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Yet, homozygous carriers of a common haplotype carry a premature stop codon in the ARMS2 gene (R38X) and therefore lack ARMS2, but this variant is not associated with AMD.
|
26427389 |
2016 |
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
After adjustment for AMD, age and gender, EMD were neither associated with CFH (p=0.11) nor with ARMS2 (p=0.45) genotypes.
|
26614632 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Patients were genotyped to identify major single nucleotide polymorphisms associated with AMD (CFH Y402, CFH I62V, and ARMS2 A69S).
|
27521170 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Odds ratios, especially for the main risk polymorphisms in ARMS2 (rs10490924) and CFH (rs1061170), gained with increasing disease severity and bilateralism (exemplarily: rs1061170: unilateral early AMD: OR = 1.18; bilateral early AMD: OR = 1.20; unilateral intermediate AMD: OR = 1.28; bilateral intermediate AMD: OR = 1.39, unilateral geographic atrophy (GA): OR = 1.50; bilateral GA: OR = 1.71).
|
27257685 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotype analyses were performed for ten common AMD-associated nuclear risk alleles (ARMS2, TNFRSF10A, CFH, C2, C3, APOE, CETP, LIPC, VEGF and COL10A1) and mtDNA haplogroups.
|
26854823 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Patients with GA were significantly older, with a higher prevalence of reticular pseudodrusen, bilateral involvement of advanced AMD and T-allele frequency of ARMS2 A69S compared with those with typical AMD and PCV; although there were no differences in the genetic and clinical characteristics among patients with GA and RAP.
|
26918864 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Healthy older participants (>50 years; n = 24) were genotyped for AMD risk genes CFH and/or ARMS2 and retinal sensitivity was compared between genotypes.
|
27225020 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
It lies next to the ARMS2/HTRA1 genes in a region of chromosome 10q26, where single nucleotide variants have been strongly associated with age-related macular degeneration (AMD), the commonest cause of blindness in Western populations.
|
27416785 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No differential methylation site reached genome-wide significance; however, when epigenetic changes in and around known GWAS-defined AMD risk loci were explored, we found small but significant DNA methylation differences in the blood of neovascular AMD patients near age-related maculopathy susceptibility 2 (ARMS2), a top-ranked GWAS locus preferentially associated with neovascular AMD.
|
26067391 |
2015 |
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that calcium, ARMS2 genotype, C. pneumonia infection, and age are significant factors in the development of the early stages of AMD.
|
25792034 |
2015 |