|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
<i>In vitro</i> knockdown of KMT5A expression in 786-O cells inhibited cell migration and invasion.
|
31186699 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
<i>SET8</i>-knockdown inhibited renal carcinoma 786-O cell proliferation, migration and invasion. c-Myc and matrix metalloproteinase-7 mRNA expression were downregulated upon <i>SET8</i>-knockdown in renal carcinoma 786-O cells.
|
29250163 |
2017 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SET8 expression is associated with overall survival in gastric cancer.
|
26634528 |
2015 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SET8 expression is associated with overall survival in gastric cancer.
|
26634528 |
2015 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
SETD8 was identified as a direct target of miR-127-3p, and SETD8 expression decreased post miR-127-3p overexpression, while SETD8 overexpression could reverse the potential influence of miR-127-3p on the migration and invasion of OS cells.
|
26707641 |
2016 |
|
Mammary Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
SET8 expression was significantly higher in breast tumor tissue than in paired adjacent normal tissue.
|
27144429 |
2016 |
|
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
SETD8 reprograms breast cancer cell metabolism through hypoxia-inducible factor 1α (HIF1α) mediated process.
|
28089831 |
2017 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
SETD8 reprograms breast cancer cell metabolism through hypoxia-inducible factor 1α (HIF1α) mediated process.
|
28089831 |
2017 |
|
Neoplasm Metastasis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
SET domain containing (lysine methyltransferase) 8 (SET8) is the sole lysine methyltransferase that catalyzes the monomethylation of histone H4 lysine 20, and is associated with tumor growth, invasion and metastasis.
|
29250163 |
2017 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
SETD8 (named PR-SET7 or KMT5a) has been reported to regulate various biological processes including carcinogenesis.
|
29487005 |
2018 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
N-lysine methyltransferase KMT5A serves a crucial role in the progression of human cancer; however, the function of KMT5A in the development of ccRCCs has not yet been investigated, which has triggered an interest in investigating the potential association between KMT5A and ccRCC.
|
31186699 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
N-lysine methyltransferase KMT5A serves a crucial role in the progression of human cancer; however, the function of KMT5A in the development of ccRCCs has not yet been investigated, which has triggered an interest in investigating the potential association between KMT5A and ccRCC.
|
31186699 |
2019 |
|
Malignant Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
A single-nucleotide polymorphism (SNP) locus rs16917496 (T > C) within the 3'-untranslated region (3'-UTR) of SET8 was associated with susceptibility in several malignancies including breast cancer.
|
27144429 |
2016 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Activation of miR‑335 or inactivation of SETD8 could be a novel approach for the treatment of breast cancer.
|
28731125 |
2017 |
|
Breast Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Activation of miR‑335 or inactivation of SETD8 could be a novel approach for the treatment of breast cancer.
|
28731125 |
2017 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
An increase of methylated PCNA was found in cancer cells, and the expression levels of SETD8 and PCNA were correlated in cancer tissue samples.
|
22556262 |
2012 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
An increase of methylated PCNA was found in cancer cells, and the expression levels of SETD8 and PCNA were correlated in cancer tissue samples.
|
22556262 |
2012 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
As such, it is predicted that SET8 might be involved in the development and progression of tumour.
|
21983900 |
2012 |
|
Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on our results, we suggest that SETD8 has a critical role mediating Group 3 MB tumorigenesis.
|
30626740 |
2019 |
|
Childhood Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on our results, we suggest that SETD8 has a critical role mediating Group 3 MB tumorigenesis.
|
30626740 |
2019 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on our results, we suggest that SETD8 has a critical role mediating Group 3 MB tumorigenesis.
|
30626740 |
2019 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Based on our results, we suggest that SETD8 has a critical role mediating Group 3 MB tumorigenesis.
|
30626740 |
2019 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Both in vitro and in vivo studies revealed that SET8 deficiency conferred an impaired glucose metabolism phenotype and thus inhibited the progression of HCC tumors.
|
30952833 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both L3MBTL1 and SET domain-containing protein 8 were upregulated in the central nervous systems of mouse models of amyotrophic lateral sclerosis and human patients with amyotrophic lateral sclerosis/frontotemporal dementia.
|
31061493 |
2019 |
|
Pick Disease of the Brain
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both L3MBTL1 and SET domain-containing protein 8 were upregulated in the central nervous systems of mouse models of amyotrophic lateral sclerosis and human patients with amyotrophic lateral sclerosis/frontotemporal dementia.
|
31061493 |
2019 |