|
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
<i>In vitro</i> knockdown of KMT5A expression in 786-O cells inhibited cell migration and invasion.
|
31186699 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, we found that miR-217 abolished the stimulation effect of SETD8 on cell proliferation and invasion.
|
30522554 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, we observed that upregulation of SETD8 reversed the effects of overexpressing of miR-384 on the proliferation, migration, and invasion of OS.
|
29630102 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Transwell assays revealed that cell migration and invasion were suppressed in KMT5A-knockdown cells.
|
29512765 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, knockdown or overexpression of XLOC_006390 and SET8 expression suppressed or promoted cervical cancer cell proliferation, migration and invasion in vitro, respectively.
|
28534991 |
2017 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
<i>SET8</i>-knockdown inhibited renal carcinoma 786-O cell proliferation, migration and invasion. c-Myc and matrix metalloproteinase-7 mRNA expression were downregulated upon <i>SET8</i>-knockdown in renal carcinoma 786-O cells.
|
29250163 |
2017 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
SETD8 was identified as a direct target of miR-127-3p, and SETD8 expression decreased post miR-127-3p overexpression, while SETD8 overexpression could reverse the potential influence of miR-127-3p on the migration and invasion of OS cells.
|
26707641 |
2016 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The subsequent assay also showed the markedly inhibition of ESCC cell migration and invasion by SET8 knock down.
|
27605386 |
2016 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We observed that curcumin suppressed cell growth, migration and invasion, and induced cell apoptosis, which is associated with increased expression of miR-7 and subsequently decreased expression of SET8, one of the miR-7 targets.
|
25256401 |
2014 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Together, our experiments revealed a novel role for SET8 in tumour invasion and metastasis and provide a molecular mechanism underlying TWIST-promoted EMT, suggesting SET8 as a potential target for intervention of the metastasis of breast cancer.
|
21983900 |
2012 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
N-lysine methyltransferase KMT5A serves a crucial role in the progression of human cancer; however, the function of KMT5A in the development of ccRCCs has not yet been investigated, which has triggered an interest in investigating the potential association between KMT5A and ccRCC.
|
31186699 |
2019 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Recruitment of a cellular deubiquitinase to stabilize key cellular proteins is an important activity of oncogenic E6, and the importance of E6-USP46-Cdt2-Set8 pathway in HPV-induced cancers makes USP46 a target for the therapy of such cancers.
|
30415951 |
2018 |
|
Malignant neoplasm of breast
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
This study determined that genetic changes in miR-146a and the miR-502 binding site of the SET8 can be effective on the increased risk of breast cancer.
|
29128203 |
2017 |
|
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
SETD8 reprograms breast cancer cell metabolism through hypoxia-inducible factor 1α (HIF1α) mediated process.
|
28089831 |
2017 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Activation of miR‑335 or inactivation of SETD8 could be a novel approach for the treatment of breast cancer.
|
28731125 |
2017 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
However, the contribution of SETD8 to metabolism reprogramming, one hallmark of cancer, has never been reported.
|
28089831 |
2017 |
|
Breast Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
SETD8 reprograms breast cancer cell metabolism through hypoxia-inducible factor 1α (HIF1α) mediated process.
|
28089831 |
2017 |
|
Breast Carcinoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
This study determined that genetic changes in miR-146a and the miR-502 binding site of the SET8 can be effective on the increased risk of breast cancer.
|
29128203 |
2017 |
|
Breast Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Activation of miR‑335 or inactivation of SETD8 could be a novel approach for the treatment of breast cancer.
|
28731125 |
2017 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, high expression of SET8 was significantly associated with poor overall survival (OS) and disease free survival (DFS) of breast cancer.
|
27080302 |
2016 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
To further elucidate the prognostic relevance of this SNP in breast cancer, we conducted a clinical study as well as SET8 expression analysis in a cohort of 1,190 breast cancer patients.
|
27144429 |
2016 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Thus, the miR-502/SET8 regulatory circuit emerges as a key regulator of the pathobiology of cancer and a focal point for possible therapeutic intervention.
|
27080302 |
2016 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Mounting evidence suggested that histone H4K20-specific methyltransferase SET8 is required to maintain the malignant phenotype of various cancer types; however, the role of SET8 in mediating tumor metastasis in prostate cancer (PCa) has remained elusive.
|
26717907 |
2016 |
|
Malignant Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
A single-nucleotide polymorphism (SNP) locus rs16917496 (T > C) within the 3'-untranslated region (3'-UTR) of SET8 was associated with susceptibility in several malignancies including breast cancer.
|
27144429 |
2016 |