KMT5A, lysine methyltransferase 5A, 387893

N. diseases: 49; N. variants: 4
Disease: Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 Biomarker group BEFREE Taken together, our data provide solid evidence that miR-217 functions as tumor suppressor in OS, and its tumor-suppressive effect is exerted through interaction with SETD8. 30522554 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 Biomarker group BEFREE Immunohistochemical staining for SET8 and PRMT5 was performed on paraffin-embedded tumor tissue microarrays. 30127976 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 Biomarker group BEFREE These data indicated that SET8 may be a functional tumor promoter and that its activation, which is partially regulated by changing the miR-502 and <i>SET8</i> 3'UTR binding affinity, may serve an important role in ccRCC development. 29250163 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 Biomarker group BEFREE By contrast, pevonedistat-induced transient growth suppression was independent of p21 or SET8, and insufficient to inhibit tumor growth in vivo. 27333051 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 Biomarker group BEFREE As such, it is predicted that SET8 might be involved in the development and progression of tumour. 21983900 2012