LAG3, lymphocyte activating 3, 3902

N. diseases: 154; N. variants: 3
Disease: Autoimmune Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.030 Biomarker group BEFREE Our study suggests that LAG3 intrinsically limits T<sub>reg</sub> proliferation and function at inflammatory sites, promotes autoimmunity in a chronic autoimmune-prone environment, and may contribute to T<sub>reg</sub> insufficiency in autoimmune disease. 28783703 2017
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.030 Biomarker group BEFREE Nonetheless, in future applications, it could also be engineered for treatment of autoimmune diseases by target depletion of LAG3-effector T lymphocytes. 28934318 2017
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.030 AlteredExpression group BEFREE LAG3 upregulation is required to control overt activation and prevent the onset of autoimmunity. 28258692 2017