LAMC1, laminin subunit gamma 1, 3915

N. diseases: 57; N. variants: 17
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.050 AlteredExpression disease BEFREE Thus, we speculated that Lamc1 was implicated in the progression of HCC probably by regulating PKM2 expression through PTEN/AKT pathway. 30755064 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.050 AlteredExpression disease BEFREE Overexpression of LAMC1 predicts poor prognosis and enhances tumor cell invasion and migration in hepatocellular carcinoma. 28928891 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.050 Biomarker disease BEFREE Importantly, LAMC1 MREs promote HCC malignancy by absorbing miR-124 and by assisting CD151 expression. 28524360 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.050 Biomarker disease BEFREE Consistently, in severe liver fibroses (n=66) and in HCCs containing fibrous nests, weighted correlation analysis revealed a gene network including the myofibroblast marker ACTA2, the basement membrane components COL4A1 and LAMC1, the Wnt pathway members FZD1; FZD7; WNT2; LEF1; DKK1 and the Secreted Frizzled Related Proteins (SFRPs) 1; 2 and 5. 27545991 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.050 GeneticVariation disease BEFREE We have investigated the role of the transcription factor Sp1 in the activation of the LamC1 gene, which encodes laminin-gamma1, both in hepatocytes and in human hepatocellular carcinomas. 9403717 1997