Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Lipocalin 2 (Lcn2) deficient mice are more prone to diet-induced obesity and metabolic dysfunction, indicating a protective role for Lcn2 in younger mice.
|
30928474 |
2019 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
We conclude that LCN2 is dispensable for both high fat diet-induced obesity and its therapeutic reduction by celastrol.
|
31488870 |
2019 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The adipokine lipocalin 2 (LCN2) has been implicated in inflammation and obesity.
|
31496871 |
2019 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Serum LCN2 level was significantly higher in women with obesity than in the controls with normal BMI (102.70 ± 27.19 vs. 80.66 ± 19.55 ng/mL, P = 0.009).
|
31147821 |
2019 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Metabolic inflammation, as observed in diabetes and obesity, has been closely associated with the upregulation of LCN2 in blood plasma and several tissues in both humans and rodents, suggesting its pro-diabetic and pro-obesogenic role.
|
31476294 |
2019 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
According to our results, although serum KIM-1, NGAL, OPN, MMP-9, and urine MMP-9, urine KIM-1 do not appear to be ideal markers to evaluate renal injury in the early period of obesity, the serum levels of cystatin C and urine NGAL, urine OPN can be used as a good marker for assessing the renal effect of obesity which can lead end stage renal disease in pediatric population.
|
30035656 |
2018 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
TM, copeptin, HMGB1, and LCN2 levels were significantly increased in overweight/obese AIS patients and in AIS patients with NIHSS score ≥ 7 when compared to other groups (p value=, ˂ 0.001*).
|
29637447 |
2018 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the interrelationships between three bone-derived factors [serum osteocalcin (OCN), fibroblast growth factor (FGF) 23, and neutrophil gelatinase-associated lipocalin (NGAL) levels] and body fat content and distribution, in order to reveal the potential endocrine function of bone in the development of obesity.
|
30424752 |
2018 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effects of Lcn2 depletion on diet-induced obesity, inflammation, and PDAC development.
|
28249896 |
2017 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive.
|
29138470 |
2017 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Lipocalin-2 (LCN-2) is an inflammatory adipocytokine and obesity-related marker of low-grade inflammation.
|
28116808 |
2017 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Two members of the lipocalin family, lipocalin-2 (LCN-2) and retinol binding protein -4 (RBP-4), play an important role in obesity and insulin resistance.
|
28279688 |
2017 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
LCN2 regulates lipid and energy metabolism in obesity and is upregulated in response to insulin.
|
29234288 |
2017 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The adipokine lipocalin 2 is linked to obesity and metabolic disorders.
|
26973291 |
2016 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression.
|
25468909 |
2015 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Plasma NGAL may play a role in the development of insulin resistance in GDM, and the high levels of NGAL expression in SAT in overweight women with GDM suggests that NGAL in SAT is associated with obesity in women with GDM.
|
24530115 |
2014 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Mice lacking lipocalin-2 are protected from dietary obesity-induced cardiovascular dysfunctions.
|
24721803 |
2014 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Lipocalin 2 (LCN2) has been related to obesity, insulin resistance and metabolic disturbance.
|
23426707 |
2013 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present work was to evaluate the effect of obesity and iron status on gene expression levels of STEAP-4 and NGAL in visceral adipose tissue (VAT) and its implication in inflammation.
|
23179203 |
2013 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Obesity increased serum chemerin and lipocalin-2 levels and tended to decrease omentin-1, irrespective of PCOS.
|
23337724 |
2013 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Lipocalin-2 is a novel adipokine that promotes FatOx and TEE and its function may be impaired in obesity.
|
23640923 |
2013 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our results revealed that the circulating level of LCN2 is associated with obesity and BMI.
|
21455126 |
2011 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Lipocalin-2 is recently recognized as a biomarker of obesity and inflammation, which are both risk factors for hypertension.
|
21978028 |
2011 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present work was to evaluate the effect of obesity on circulating concentrations and gene and protein expression levels of LCN2 in human visceral adipose tissue (VAT) as well as its involvement in inflammation.
|
19466389 |
2009 |
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
Herein we show that the levels of LCN2 mRNA are dramatically increased in adipose tissue and liver of ob/ob mice and primary adipose cells isolated from Zucker obese rats, and thiazolidinedione administration reduces LCN2 expression.
|
18292240 |
2008 |