LCT, lactase, 3938

N. diseases: 90; N. variants: 14
Disease: Lactose Intolerance ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022951
Disease: Lactose Intolerance
Lactose Intolerance 		0.200 AlteredExpression disease BEFREE Lactose intolerance is the most common intestinal disorder that is associated with an absence or drastically reduced levels of an intestinal enzyme, in this case lactase-phlorizin hydrolase (LPH). 11332711 2001
CUI: C0022951
Disease: Lactose Intolerance
Lactose Intolerance 		0.200 AlteredExpression disease BEFREE Because the hypolactasia of malnourished children was associated with much lower lactase than sucrase mRNA abundance and because the epigenetic suppression, which accounted for the reduction of sucrase mRNA, was inadequate to explain the greater reduction of lactase mRNA, this study concludes that malnutrition suppresses lactase gene transcription or mRNA stability in infants. 9041235 1997
CUI: C0022951
Disease: Lactose Intolerance
Lactose Intolerance 		0.200 AlteredExpression disease BEFREE The term lactase deficiency is widely used to indicate a low or absent level of lactase enzyme in the small intestine, leading to lactose intolerance. 7820203 1994
CUI: C0022951
Disease: Lactose Intolerance
Lactose Intolerance 		0.200 AlteredExpression disease BEFREE Lactose intolerance and the genetic regulation of intestinal lactase-phlorizin hydrolase. 1916106 1991
CUI: C0022951
Disease: Lactose Intolerance
Lactose Intolerance 		0.200 Biomarker disease HPO