|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PCR-based genotyping of lactase (LCT) gene polymorphisms is a safe and easy way to diagnose ALI and may complement diagnostic procedures to identify individuals at risk for reduced calcium intake and subsequently osteoporosis due to lactose malabsorption.
|
31802224 |
2019 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lactose intolerance can be evaluated by means of the Lactose Breath Test (phenotype) and/or genetic evaluation of lactase-gene polymorphism (genotype).
|
31226742 |
2019 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Example associations included validation of known associations between FUT2 secretor status, as well as a variant conferring hypolactasia near the LCT gene, with Bifidobacterium longum abundance in stool.
|
29378630 |
2018 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, an intermediate lactose intolerance (LI) phenotype based on the lactase gene (LCT) C/T<sub>-13910</sub> polymorphism was proposed.
|
27593109 |
2017 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several studies suggested that the identification of C/T-13910 and G/A-22018 mutations, located upstream the gene encoding the lactase-phlorizin hydrolase (LPH), is a useful tool for the differential diagnosis of hypolactasia.
|
25281930 |
2015 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The LCT C>T-13910 variant was genotyped by RT-PCR in 121 volunteers and lactose malabsorption was assessed using the hydrogen breath test (HBT) after consuming 25 g of lactose.
|
25096822 |
2014 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of the GG (LCT-22018G/A) adult hypolactasia genotype among those groups was identical to that of the CC genotype in each group, except for Iraqi-Jews, of which only 83% carried the GG genotype.
|
23415628 |
2013 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A total of 153 healthy volunteers (76 from southern and 77 from northern India) were evaluated for LM by using a lactose tolerance test (LTT), a lactose hydrogen breath test (lactose HBT), and polymerase chain reaction-restriction fragment length polymorphism to identify the lactase gene C/T-13910 polymorphism (confirmed by sequencing).
|
19889824 |
2010 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The CC genotype of the 13910 C/T polymorphism of the LCT gene is linked to lactose intolerance and low calcium intake.
|
18704543 |
2009 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The molecular basis of inherited hypolactasia has yet to be identified, though two polymorphisms in the introns of a helicase upstream from the lactase gene correlate closely with hypolactasia, and thus lactose intolerance.
|
19960866 |
2009 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Single nucleotide polymorphism C/T(-13910), located upstream of the lactase gene, associated with adult-type hypolactasia: validation for clinical practice.
|
18237552 |
2008 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We examined genetic polymorphisms that might influence calcium metabolism: lactase (LCT) gene 13910 C/T polymorphism causing lactose intolerance and calcium-sensing receptor (CaSR) gene A986S polymorphism as a responsible factor for the altered cellular calcium sensation.
|
18980667 |
2008 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Patients presenting with symptoms of lactose intolerance are in some centres routinely tested for a single-nucleotide polymorphism C-13910T, which is located upstream of the lactase gene (LCT) and is tightly associated with genetically determined lactase persistence/non-persistence.
|
17651714 |
2007 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To examine a relationship of molecularly defined lactose malabsorption (LM; by LCT-polymorphism) to calcium supply, bone mineral density (BMD) and parameters of bone metabolism in an elderly male cohort.
|
17318022 |
2007 |
|
Lactose Intolerance
|
0.200 |
Biomarker
|
disease |
BEFREE |
LCT genotyping and functional lactose malabsorption tests were highly correlated.
|
17103297 |
2007 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Using automated DNA purification on the MagNA Pure LC and real-time PCR on the LightCycler, we examined samples from 220 individuals to estimate genotype frequencies; we then determined LPH C-->T(-13910) genotype in samples from 54 Caucasian patients with a positive LBHT result and symptoms of lactose intolerance.
|
16391332 |
2006 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The correlation between LCT genotype and self-reported milk-intolerance or dislike of milk with was slight, but the correlation with functional tests was highly significant.
|
16299058 |
2005 |
|
Lactose Intolerance
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Lactase non-persistence (adult-type hypolactasia and lactose intolerance) is characterized by a decline in the expression of lactase-phlorizin hydrolase (LPH) after weaning.
|
16301215 |
2005 |
|
Lactose Intolerance
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The frequency of the genotype C/C(-13910) associated with adult-type hypolactasia (low lactase enzyme activity or primary lactose malabsorption (LM)) was significantly greater in individuals with hip fractures, with an adjusted odds ratio (OR) of 3.7 (95% confidence interval (CI)=1.8-7.8), wrist fractures with an adjusted OR of 2.5 (95% CI=1.2-5.2), and hip and wrist fractures combined with an adjusted OR of 4.1 (95% CI=2.0-8.3).
|
15667380 |
2005 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The molecular basis of inherited hypolactasia has yet to be identified, though two polymorphisms in the introns of a helicase upstream from the lactase gene correlate closely with hypolactasia, and thus lactose intolerance.
|
16805112 |
2005 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PCR-based genotyping of lactase gene polymorphisms may complement diagnostic procedures to identify persons at risk for both lactose malabsorption and osteoporosis.
|
14753735 |
2004 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Biochemical methods for assessing lactose malabsorption in the form of the lactose breath hydrogen test and direct lactase enzyme activity performed on small intestinal tissue biopsy samples may also be utilized.
|
15287817 |
2004 |
|
Lactose Intolerance
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Lactose malabsorption (LM; adult-type hypolactasia), an autosomal recessive condition, results from the down-regulation of the activity of lactase enzyme in the intestinal wall.
|
15365657 |
2004 |
|
Lactose Intolerance
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two DNA genotypes, C/C(-13910) and G/G(-22018), located upstream from the LCT locus, the gene encoding for LPH, were recently identified as representing genetic markers for lactose intolerance.
|
12795467 |
2003 |
|
Lactose Intolerance
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Adult-type hypolactasia, also known as lactase non-persistence (lactose intolerance), is a common autosomal recessive condition resulting from the physiological decline in activity of the lactase-phlorizin hydrolase (LPH) in intestinal cells after weaning.
|
11788828 |
2002 |