LDHA, lactate dehydrogenase A, 3939

N. diseases: 185; N. variants: 0
Disease: Secondary Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.050 Biomarker group BEFREE Both <i>in vivo</i> and <i>in vitro</i> experiments suggest that high lactate levels may be necessary for tumor cell growth, as small molecules inhibitors of lactate dehydrogenase (LDH5/LDHA) decrease both the rate of tumor growth and formation of metastases. 31297386 2019
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.050 GeneticVariation group BEFREE These changes resulted in a greater delay in metastases formation and 40% long-term survivors (>20 weeks) in the LDH-A KD cohort following surgical resection of the primary tumor. 30248111 2018
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.050 Biomarker group BEFREE LDHA promotes tumor metastasis by facilitating epithelial‑mesenchymal transition in renal cell carcinoma. 28983605 2017
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.050 GeneticVariation group BEFREE In addition, LDHA knockdown or LDHA Y10F rescue expression in human cancer cells resulted in decreased tumour metastasis in xenograft mice. 28218905 2017
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.050 Biomarker group BEFREE We show for the first time that LDH-A knockdown inhibited the formation of metastases, and was accompanied by in vivo changes in tumor cell metabolism. 23833310 2013