|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
So, with their ability to affect lipid levels, the LDLR, ApoB and ApoE polymorphisms could be one of the factors influencing development of atherosclerosis.
|
27236033 |
2016 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice.
|
10974047 |
2000 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the low-density lipoprotein receptor (LDLR) gene resulting in familial hypercholesterolemia have strong association with premature atherosclerosis.
|
12476935 |
2002 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
LDL receptor-related protein with 11 ligand binding repeat (LR11) and its soluble form (sLR11) play a role in the progression of atherosclerosis.
|
26520897 |
2015 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice.
|
30567482 |
2019 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
PCSK9 could accelerate atherosclerosis through mechanisms beyond the degradation of the hepatic low-density lipoprotein receptor.
|
28535426 |
2017 |
|
Atherosclerosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Inflammation relevant genes, such as F4/80, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, and monocyte chemoattractant protein (MCP)-1, and lipid metabolism associated gene, such as LDL receptor, class A scavenger receptors (SR-A), scavenger receptor class B type I (SR-BI), CD36, ATP binding cassette subfamily A member 1 (ABCA1), and ATP binding cassette subfamily G member 1 (ABCG1) in the aorta were significantly down-regulated in miR-217 group when compared with atherosclerosis group.
|
30041636 |
2018 |
|
Atherosclerosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Chow-fed hypomorphic Apoe mice deficient in low-density lipoprotein receptor expression (Apoe(h/h)Ldlr(-/-)Mx1-cre mice) develop hyperlipidemia and atherosclerosis.
|
23788760 |
2013 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We have previously shown that low density lipoprotein receptor knockout mice overexpressing LPL are resistant to diet-induced atherosclerosis due to the suppression of remnant lipoproteins.
|
10484615 |
1999 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We studied the effects of inulin on lipid metabolism with a model of atherosclerosis in LDL receptor-deficient mice using lipidomics and transcriptomics.
|
31604806 |
2020 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study we analyzed the impact of different FXR agonists on cholesterol homeostasis, plasma lipoprotein profiles, and transhepatic cholesterol efflux in C57BL/6J mice and cynomolgus monkeys and atherosclerosis development in cholesteryl ester transfer protein transgenic (CETPtg) low-density lipoprotein receptor (LDLR) (-/-) mice.
|
22918042 |
2012 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We generated myeloid cell-specific Ncor1 knockout mice and crossbred them with low-density lipoprotein receptor (Ldlr) knockouts to study the role of macrophage NCOR1 in atherosclerosis.
|
31529020 |
2020 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to evaluate the effects of dihydromyricetin on high fat diet (HFD)-induced atherosclerosis using LDL receptor deficient (LDLr<sup>-/-</sup>) mice.
|
28500865 |
2017 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (II) - Contribution to the Development and Validation of the Therapeutics for Hypercholesterolemia and Atherosclerosis.
|
31748470 |
2020 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the molecular mechanism for changes in proteoglycan binding and LDL receptor affinity on two compositional changes in LDL that have been associated with atherosclerosis: cholesterol enrichment of the core and modification by secretory group IIA phospholipase A2 (sPLA2) of the surface.
|
14726411 |
2004 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Genetically modified mouse models, particularly mice deficient in apoprotein E or the LDL receptor, have been widely used in preclinical atherosclerosis studies to gain insight into the mechanisms underlying this pathology.
|
26445778 |
2015 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We addressed the impact of Clec4e activation on macrophage functions in vitro and on the development of atherosclerosis using low-density lipoprotein receptor-deficient (Ldlr<sup>-/-</sup>) mice in vivo.
|
27587433 |
2016 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
LDLR KO along with LDLR/apoE double KO rabbits should provide a novel means for translational investigations of human hyperlipidemia and atherosclerosis.
|
30885208 |
2019 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Paradoxically, <i>Ldlr</i><sup>-/-</sup> (low-density lipoprotein receptor null) mice deficient in <i>miR-146a</i> develop less atherosclerosis, despite having highly elevated levels of circulating proinflammatory cytokines.
|
28637783 |
2017 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We conclude that LDLR-/-; Tg(apoB+/+) mice exhibit accelerated atherosclerosis on a chow diet and thus provide an excellent animal model in which to study atherosclerosis.
|
9539774 |
1998 |
|
Atherosclerosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels, and atherosclerosis in LDL receptor knockout mice on high-fat diet.
|
20724582 |
2010 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To date, mutations in the low-density lipoprotein receptor gene (LDLR) are the only identified causes of FH in the Greek population, causing high levels of low-density lipoprotein (LDL) and total cholesterol and premature atherosclerosis.
|
23815734 |
2013 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results suggest that the fourth cysteine residue of the first ligand-binding domain of the LDLR might be important for the internalization of atherogenic lipoproteins by vascular cells despite reduced LDL uptake, leading to atherosclerosis and premature cardiovascular disease.
|
15459764 |
2004 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
|
6390206 |
1984 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A modest increase in hepatic LXRalpha worsened serum lipid profiles in LDL-receptor null mice fed normal chow but had the opposite effect on lipids and afforded strong protection against atherosclerosis on a Western diet.
|
16054077 |
2005 |