|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We still need to know which tissues take up the most LDL; we need to know how much LDL is cleared by the liver and whether this clearance involves the same LDL receptor that operates in extra-hepatic cells; we need to know the mechanism for the clearance of the one-half to two-thirds of LDL that leaves the plasma by receptor-independent pathways; and finally we need to know how an abnormal accumulation of LDL in the plasma leads to the deposition of cholesterol in scavenger cells and produces atherosclerosis.
|
6994567 |
1980 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
|
6390206 |
1984 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We compare the nucleotide sequences of the region encompassing the putative LDL receptor-binding sites from four pig alleles, including one implicated directly in atherosclerosis.
|
2905687 |
1988 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mutations in another genetic locus, the low density lipoprotein (LDL) receptor gene, give rise to familial hypercholesterolemia (FH), a disease characterized by hypercholesterolemia, tendon xanthomas and atherosclerosis.
|
2567693 |
1989 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Defects in the low density lipoprotein receptor gene affect lipoprotein (a) levels: multiplicative interaction of two gene loci associated with premature atherosclerosis.
|
2524837 |
1989 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Aortic and coronary atheromatosis in a woman with severe hypercholesterolaemia without LDL receptor alterations.
|
1889447 |
1991 |
|
Atherosclerosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
To determine the effects of the overexpressed LPL on diet-induced atherosclerosis, we have generated low density lipoprotein receptor (LDLR) knockout mice that overexpressed human LPL transgene (LPL/LDLRKO) and compared their plasma lipoproteins and atherosclerosis with those in nonexpressing LDLR-knockout mice (LDLRKO).
|
8692976 |
1996 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Familial hypercholesterolemia (FH) results from an inherited functional defect of the low density lipoprotein (LDL) receptor and is complicated by premature atherosclerosis.
|
8808773 |
1996 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recent interest in atherosclerosis has focused on the genetic determinants of low-density lipoprotein (LDL) particle size, because of (i) the association of small dense LDL particles with a three-fold increased risk for coronary artery disease (CAD) and (ii) the recent report of linkage of the trait to the LDL receptor (chromosome 19).
|
8644718 |
1996 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Within certain families and isolated communities, the effect of a single candidate gene on atherosclerosis susceptibility may be profound, as in the case of mutations in the gene encoding the low-density lipoprotein receptor, which produce familial hypercholesterolemia and premature atherosclerosis.
|
9288444 |
1997 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Atherosclerosis in LDL-receptor knockout mice is accelerated by immunization with anticardiolipin antibodies.
|
9412988 |
1997 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
A synergistic interaction between the apolipoprotein C-III and the LDL receptor defects produced large quantities of VLDL and LDL and enhanced the development of atherosclerosis.
|
8994037 |
1997 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We conclude that LDLR-/-; Tg(apoB+/+) mice exhibit accelerated atherosclerosis on a chow diet and thus provide an excellent animal model in which to study atherosclerosis.
|
9539774 |
1998 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This observation could explain the higher incidence of atherosclerosis in male LDL-R deficient mice and human familial hypercholesterolemia (FH) patients.
|
9642116 |
1998 |
|
Atherosclerosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In contrast, mice deficient for the LDL receptor (Ldlr-/-) have only mildly elevated LDL cholesterol levels and little atherosclerosis.
|
9701246 |
1998 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the low density lipoprotein (LDL)-receptor gene cause familial hypercholesterolemia (FH), an autosomal dominant disease associated to an increased risk of premature atherosclerosis.
|
10660340 |
1998 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Familial hypercholesterolemia (FH), a monogenic disease known to be caused by low-density lipoprotein receptor (LDLR) gene mutations, results in the development of premature atherosclerosis and coronary artery disease in affected individuals.
|
9889019 |
1998 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Low-density lipoprotein receptor-related protein in atherosclerosis development: up-regulation of gene expression in patients with coronary obstruction.
|
9694437 |
1998 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We have previously shown that low density lipoprotein receptor knockout mice overexpressing LPL are resistant to diet-induced atherosclerosis due to the suppression of remnant lipoproteins.
|
10484615 |
1999 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
E2 protected LDLR-/- female mice from atherosclerosis and this protection was independent of changes in plasma cholesterol levels.
|
10224158 |
1999 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression.
|
10195942 |
1999 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Nonparametric analysis indicated significant linkage of the LDL receptor gene locus to aortic (p < 0.00005) and to aorto-coronary calcified atherosclerosis (p < 0.00001).
|
11246453 |
1999 |
|
Atherosclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To investigate the effects of its structural changes on lipoprotein metabolisms and its correlation with atherosclerosis, we characterized this mutant apoE with respect to its receptor-binding, heparin-binding, and lipoprotein association.In a competitive binding assay, apoE7. dimyristoylphosphatidylcholine displayed a defective binding to the low density lipoprotein (LDL) receptor.
|
9925654 |
1999 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Administration of antibody against CD154 to low-density lipoprotein receptor-deficient mice has been shown to reduce atherosclerosis and decrease T-lymphocyte and macrophage content; however, only initial lesions were studied.
|
10546000 |
1999 |
|
Atherosclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice.
|
10974047 |
2000 |