LEP, leptin, 3952

N. diseases: 931; N. variants: 15
Disease: Presenile dementia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 Biomarker disease BEFREE Studies suggest that leptin, an adipokine, has a neuroprotective role against Alzheimer's disease (AD) and that cytokines are associated with inflammatory processes and dementia. 30150062 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 AlteredExpression disease BEFREE We explored associations of concurrent BMI, WHR, and blood leptin and high molecular weight adiponectin levels with dementia occurrence. 29758945 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 Biomarker disease BEFREE Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia. 28421328 2017
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 Biomarker disease BEFREE In addition to this evidence linking leptin to neural plasticity and function, observational studies evaluating leptin-sufficient humans have also demonstrated direct correlation between blood leptin levels and brain volume and inverse associations between circulating leptin and risk for the development of dementia. 26881138 2016
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 Biomarker disease BEFREE Some authors proposed that leptin evaluation might be a better predictor of dementia than traditional anthropometric measures. 26279362 2015
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.350 Therapeutic disease CTD_human Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. 20157255 2010