Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mathematical model of diabetes and lipid metabolism linked to diet, leptin sensitivity, insulin sensitivity and VLDLTG clearance predicts paths to health and type II diabetes.
|
31626814 |
2020 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
GDF-15 (hypertension + diabetes) and LEP (hypertension + obesity) are shared by 2 different phenotypes.
|
31062082 |
2020 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Breast cancer patients receiving metformin as treatment for diabetes showed significant reduction in levels of insulin, fasting glucose, CRP, HOMA, leptin, BMI, and Ki-67.
|
31006835 |
2020 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, CB1 activation is linked to impaired lipid and glucose metabolism and therefore obesity and diabetes, while its antagonism leads to the reduction of plasma triglycerides, low-density lipoprotein cholesterol, leptin, insulin and glucose.
|
30890410 |
2020 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this cross-sectional study, we measured body mass composition by dual-energy X-ray absorptiometry, wrist circumference, waist-to-height ratio, fasting blood insulin, glucose, lipid profile, adiponectin, and leptin in 280 children with overweight/obesity and without diabetes (age: 7-18 years).
|
31347024 |
2020 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Leptin, a critical mediator of feeding, metabolism and diabetes, is expressed on an incidental basis according to satiety.
|
31661517 |
2019 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The copy number of mtDNA in various fat stores was higher in obese patients with type 2 diabetes than in obese patients without diabetes or in the control subjects and was related to the levels of leptin and proinflammatory cytokines.
|
30871567 |
2019 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A higher likelihood of asthma remission was associated with a greater decrease in leptin levels, and a higher likelihood of diabetes remission was predicted by a lesser decrease in CC.
|
29777230 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diabetes was associated with severe insulin resistance and undetectable plasma leptin.
|
31434650 |
2019 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HPR was significantly related to duration of diabetes and higher fasting glucose levels (but not consistently with HbA<sub>1c</sub>), and strongly related to all markers of insulin resistance, especially waist circumference, HOMA-IR, QUICKI and leptin.
|
31783142 |
2019 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
At the end of the study, in diabetes group, blood glucose level, GLUT2 and galanin expressions increased, while leptin expression decreased when compared to control group.
|
31231496 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
When examining the correlation network by timing of diabetes onset, there were more perturbations in the network for case subjects diagnosed >10 years versus <5 years after blood collection, with consistent differential correlations of insulin and HbA<sub>1c</sub> C-peptide was the most highly connected node in the early-stage network, whereas leptin was the hub for mid- or late-stage networks.
|
30409783 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, R482 carriers had lower BMI (P < 0.05), leptin (P < 0.01) and fat mass (P < 0.001), but higher intra-/total abdominal fat-mass ratios (P < 0.001) and prevalences of diabetes (P < 0.01) and hypertriglyceridaemia (P < 0.05) than non-R482 carriers, with a trend towards more coronary artery disease.
|
30287275 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antidiabetic activities of CF might be mediated via inhibition of α-amylase and α-glucosidase activities, elevation of serum insulin concentration, and enhancement of insulin and leptin sensitivity in obesity-diabetes rats.
|
30342966 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two synthetic leptin derivatives (mimetics), OB3 and [D-Leu-4]-OB3, show more effective than leptin in reducing obesity and diabetes in mouse models.
|
31499123 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that chronic MC4R activation, even in NPY-deficient mice, does not mimic chronic antidiabetic, cardiovascular, or metabolic actions of leptin, and that NPY is not essential for hyperphagia or cardiovascular changes associated with diabetes.
|
29351428 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The leptin-resistant db/ db mouse has been extensively studied as a model of diabetes-associated cardiomyopathy; however, data on the functional and morphological alterations in db/ db hearts are conflicting.
|
30004258 |
2018 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Loss of tau also resulted in increased epididymal fat mass and leptin levels, reduced glucose production, and insulin resistance at later ages, leading to complete onset of diabetes.
|
29401605 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest significant associations between BCAA concentrations and those for adiponectin, leptin and HOMA2-IR in individuals without diabetes.
|
29348480 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Affinity kinetics of leptin-reactive immunoglobulins are associated with plasma leptin and markers of obesity and diabetes.
|
29795184 |
2018 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study assessed short-term memory and biochemical indicators with the levels of ghrelin, leptin, and cortisol between cognitive impairment and normal older adults with or without diabetes.
|
29492658 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Selective deletion of LEPR in these neurons with the Cre-loxP system, however, has previously failed to recapitulate, or only marginally recapitulated, the obesity and diabetes that are seen in LEPR-deficient Lepr <sup>db/db</sup> mice, suggesting that AGRP or POMC neurons are not directly required for the effects of leptin in vivo<sup>8-10</sup>.
|
29670283 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gut microbiota varies by opioid use, circulating leptin and oxytocin in African American men with diabetes and high burden of chronic disease.
|
29596446 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical data on patients with lipodystrophy indicates that leptin may have a positive effect on glucose metabolism in individuals with diabetes.
|
30098320 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multivariable logistic regression analysis showed that leptin (odds ratio [OR] 1.09; 95% confidence interval [CI] 1.04-1.14; p <0.001), diabetes (OR 7.17; CI 1.39-37.00; p = 0.019), body fat mass (OR 1.16; CI 1.02-1.33; p = 0.027); and hemoglobin (OR 2.11; CI 1.15-3.87; p = 0.015) were independently associated with arterial stiffness in HD patients.
|
29304064 |
2018 |