Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
We examined the relationship of plasma leptin with cortical and trabecular bone components in patients with type 2 diabetes mellitus.
|
31074113 |
2020 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Breast cancer patients receiving metformin as treatment for diabetes showed significant reduction in levels of insulin, fasting glucose, CRP, HOMA, leptin, BMI, and Ki-67.
|
31006835 |
2020 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
GDF-15 (hypertension + diabetes) and LEP (hypertension + obesity) are shared by 2 different phenotypes.
|
31062082 |
2020 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
In this cross-sectional study, we measured body mass composition by dual-energy X-ray absorptiometry, wrist circumference, waist-to-height ratio, fasting blood insulin, glucose, lipid profile, adiponectin, and leptin in 280 children with overweight/obesity and without diabetes (age: 7-18 years).
|
31347024 |
2020 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Mathematical model of diabetes and lipid metabolism linked to diet, leptin sensitivity, insulin sensitivity and VLDLTG clearance predicts paths to health and type II diabetes.
|
31626814 |
2020 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, CB1 activation is linked to impaired lipid and glucose metabolism and therefore obesity and diabetes, while its antagonism leads to the reduction of plasma triglycerides, low-density lipoprotein cholesterol, leptin, insulin and glucose.
|
30890410 |
2020 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Two synthetic leptin derivatives (mimetics), OB3 and [D-Leu-4]-OB3, show more effective than leptin in reducing obesity and diabetes in mouse models.
|
31499123 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
After adjustment for confounders, leptin was positively associated with 25(OH)D (r=0.210, p=0.002) with similar correlation in TB patients with DM (r=0.240, p=0.020).
|
31666475 |
2019 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A higher likelihood of asthma remission was associated with a greater decrease in leptin levels, and a higher likelihood of diabetes remission was predicted by a lesser decrease in CC.
|
29777230 |
2019 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HPR was significantly related to duration of diabetes and higher fasting glucose levels (but not consistently with HbA<sub>1c</sub>), and strongly related to all markers of insulin resistance, especially waist circumference, HOMA-IR, QUICKI and leptin.
|
31783142 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Using a DM type 1 model (streptozotocin injected C57BL/6 mice) and type 2 model (leptin knockout obese db/db mice), we showed enhanced BBB permeability and memory loss (Y maze, water maze) that are associated with hyperglycemia.
|
29974394 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Diabetes was associated with severe insulin resistance and undetectable plasma leptin.
|
31434650 |
2019 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The copy number of mtDNA in various fat stores was higher in obese patients with type 2 diabetes than in obese patients without diabetes or in the control subjects and was related to the levels of leptin and proinflammatory cytokines.
|
30871567 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
'Fat's chances': Loci for phenotypic dispersion in plasma leptin in mouse models of diabetes mellitus.
|
31661517 |
2019 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lipodystrophy syndromes are rare heterogeneous disorders characterized by deficiency of adipose tissue, usually a decrease in leptin levels and, frequently, severe metabolic abnormalities including diabetes mellitus and dyslipidemia.
|
29704234 |
2019 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
At the end of the study, in diabetes group, blood glucose level, GLUT2 and galanin expressions increased, while leptin expression decreased when compared to control group.
|
31231496 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, R482 carriers had lower BMI (P < 0.05), leptin (P < 0.01) and fat mass (P < 0.001), but higher intra-/total abdominal fat-mass ratios (P < 0.001) and prevalences of diabetes (P < 0.01) and hypertriglyceridaemia (P < 0.05) than non-R482 carriers, with a trend towards more coronary artery disease.
|
30287275 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Compared to controls, patients presented significantly lower levels of cholesterol, high-density lipoprotein cholesterol (HDLc), LDLc, oxLDL, and intermediate and small HDL and higher triglycerides, CRP, adiponectin, large HDL, very-low-density lipoprotein (VLDL), and intermediate-density lipoprotein- (IDL) B. Adiponectin levels correlated positively with large HDL and negatively with intermediate and small HDL, oxLDL/LDLc, and BMI; patients with DM (<i>n</i> = 17) and with DM+HT (<i>n</i> = 70), as compared to patients without DM or HT (<i>n</i> = 69) or only with HT (<i>n</i> = 38), presented significantly higher oxLDL, oxLDL/LDLc, and leptin and lower adiponectin.
|
30911344 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
When examining the correlation network by timing of diabetes onset, there were more perturbations in the network for case subjects diagnosed >10 years versus <5 years after blood collection, with consistent differential correlations of insulin and HbA<sub>1c</sub> C-peptide was the most highly connected node in the early-stage network, whereas leptin was the hub for mid- or late-stage networks.
|
30409783 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Antidiabetic activities of CF might be mediated via inhibition of α-amylase and α-glucosidase activities, elevation of serum insulin concentration, and enhancement of insulin and leptin sensitivity in obesity-diabetes rats.
|
30342966 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest a potential link between gastric leptin and microbial-derived metabolites in the context of obesity and diabetes.
|
29851973 |
2018 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Literature searches were carried out using Medline, the Cochrane Controlled Trials Registry and ClinicalTrials.gov, and RCTs that investigated the effects of pioglitazone on blood leptin levels in patients with type 2 diabetes were selected.
|
29194996 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, this article will highlight the signifying role of leptin as a therapeutic target by indicating the targeted treatment of DM through the appropriate understanding of advanced therapeutic approaches using leptin as a treatment strategy for DM.
|
29236298 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
In the nested case control study, leptin concentrations were a significant predictor of developing diabetes (p=0.005) in unadjusted models, but not after correcting for BMI, whereas irisin concentrations did not play a role of comparable significance.
|
29108900 |
2018 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Loss of tau also resulted in increased epididymal fat mass and leptin levels, reduced glucose production, and insulin resistance at later ages, leading to complete onset of diabetes.
|
29401605 |
2018 |