LEP, leptin, 3952

N. diseases: 931; N. variants: 15
Disease: Seizures ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036572
Disease: Seizures
Seizures 		0.320 Biomarker phenotype BEFREE Rats were subdivided on P13 into control, control + leptin (leptin, 2 mg/kg/day, continuous 10 days), seizure (RS), and seizure + leptin group (RS + leptin, 2 mg/kg/day for 10 consecutive days). 30092488 2018
CUI: C0036572
Disease: Seizures
Seizures 		0.320 Biomarker phenotype BEFREE Prevalence of non-cognitive neurological manifestations in the DIAN-OBS cohort was low, including myoclonus and spasticity (9·3%, 95% CI 3·8-15·0), and seizures (2·8%, 0·5-5·9) and moderate for parkinsonism (11·2%, 5·3-17·1). 27777020 2016
CUI: C0036572
Disease: Seizures
Seizures 		0.320 Therapeutic phenotype CTD_human Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. 17993459 2008