LEP, leptin, 3952

N. diseases: 931; N. variants: 15
Disease: Alcohol withdrawal syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0236663
Disease: Alcohol withdrawal syndrome
Alcohol withdrawal syndrome 		0.330 PosttranslationalModification disease BEFREE The objective of our study was to investigate the dynamics of leptin gene promoter methylation during alcohol withdrawal and specific treatment in a rodent (rat) model for alcohol dependence. 30650427 2019
CUI: C0236663
Disease: Alcohol withdrawal syndrome
Alcohol withdrawal syndrome 		0.330 Biomarker disease PSYGENET DNA methylation of the LEP gene is associated with craving during alcohol withdrawal. 25462909 2015
CUI: C0236663
Disease: Alcohol withdrawal syndrome
Alcohol withdrawal syndrome 		0.330 PosttranslationalModification disease BEFREE DNA methylation of the LEP gene is associated with craving during alcohol withdrawal. 25462909 2015
CUI: C0236663
Disease: Alcohol withdrawal syndrome
Alcohol withdrawal syndrome 		0.330 Biomarker disease BEFREE Our results show on the one hand negative associations between the number of CAG repeats and (i) leptin serum levels (P<0.01) and (ii) craving (P<0.05), and on the other hand, a positive association between leptin and craving of man in alcohol withdrawal (P<0.001). 19884906 2010
CUI: C0236663
Disease: Alcohol withdrawal syndrome
Alcohol withdrawal syndrome 		0.330 Biomarker disease PSYGENET The modulating effect of the androgen receptor on craving in alcohol withdrawal of men is partially mediated by leptin. 19884906 2010
CUI: C0236663
Disease: Alcohol withdrawal syndrome
Alcohol withdrawal syndrome 		0.330 Biomarker disease PSYGENET Blockade of the leptin-sensitive pathway markedly reduces alcohol consumption in mice. 15547455 2004