LEPR, leptin receptor, 3953

N. diseases: 416; N. variants: 57
Disease: Amebiasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002438
Disease: Amebiasis
Amebiasis 		0.020 GeneticVariation disease BEFREE Humans with the Q223R leptin receptor mutation have increased susceptibility to amebiasis, but the mechanism has been unclear. 25516614 2014
CUI: C0002438
Disease: Amebiasis
Amebiasis 		0.020 GeneticVariation disease BEFREE These findings suggest that leptin signaling is important in mucosal defense against amebiasis and that polymorphisms in the leptin receptor explain differences in susceptibility of children in the Bangladesh cohort to amebiasis. 21393862 2011