LEPR, leptin receptor, 3953

N. diseases: 300; N. variants: 31
Disease: Hyperinsulinism ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 AlteredExpression disease BEFREE Disruption of the signal transducer and activator of transcription 3 (STAT3) in the hypothalamic neurons expressing leptin receptor, results in severe obesity, hyperglycaemia, and hyperinsulinemia. 19390493 2009
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.420 AlteredExpression disease BEFREE Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance. 11596667 2001