LEPR, leptin receptor, 3953

N. diseases: 300; N. variants: 31
Disease: Impaired glucose tolerance ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.540 Biomarker phenotype BEFREE Single nucleotide polymorphisms (SNPs) in the ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL genes were associated with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes mellitus (T2D) in the Finnish Diabetes Prevention Study (DPS). 18249219 2008
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.540 GeneticVariation phenotype BEFREE The pentanucleotide insertion/deletion polymorphism in the 3'UTR of the OB-R gene did not influence the conversion to type 2 diabetes in obese patients with IGT. 15833934 2005
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.540 GeneticVariation phenotype BEFREE Two polymorphisms (Lys109Arg, Gln223Arg) in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT. 15997246 2005
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.540 GeneticVariation phenotype BEFREE Three LEPR polymorphisms (Lys(109)Arg, Gln(223)Arg, and Lys(656)Asn) were typed on genomic DNA of 358 overweight and obese women, aged 18-60 yr. Based on an OGTT, 269 subjects were defined with normal glucose tolerance, and 89 with impaired glucose tolerance (IGT). 11443193 2001