Disease: Epileptic Seizures ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures 		0.320 Biomarker phenotype BEFREE We found that JIP3 was markedly increased in TLE patients and a mouse model of epileptic seizures; mice underexpressing JIP3 through lentivirus bearing LV-Letm1-RNAi showed decreased susceptibility, delayed first seizure and decreased seizure duration response to the epileptogenic properties of KA. 26002316 2015
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures 		0.320 Biomarker phenotype BEFREE These results indicate that inhibition of Letm1 and mitochondrial dysfunctions contributes to the development of epileptic seizures. 23645710 2014
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures 		0.320 Biomarker phenotype CTD_human LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein. 14706454 2004