LIMK2, LIM domain kinase 2, 3985

N. diseases: 44; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.110 GeneticVariation disease GWASDB A genome-wide association study for diabetic nephropathy genes in African Americans. 21150874 2011
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure 		0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0200641
Disease: Blood basophil count (lab test)
Blood basophil count (lab test) 		0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 GeneticVariation group BEFREE Limk2 deletion increased colon tumour size in a colitis-associated colorectal mouse cancer model. 23585469 2014
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 GeneticVariation phenotype BEFREE As the mechanisms of LIMK-associated tumorigenesis are still unclear, we analyzed the tumorigenic functions of LIM kinase 2 (LIMK2) in human bladder cancer (BC) and explored whether the newly identified LIMK2 3´-UTR SNP rs2073859 (G-to-A allele) is correlated with clinical features. 30006972 2019
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.020 GeneticVariation disease BEFREE PCR-Restriction Fragment Length Polymorphism (RFLP) was used to genotype LIMK2 SNP rs2073859 and multivariate logistic regression applied to assess the relationship between allele frequency and clinical features in 139 BC patients. 30006972 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.020 GeneticVariation disease BEFREE PCR-Restriction Fragment Length Polymorphism (RFLP) was used to genotype LIMK2 SNP rs2073859 and multivariate logistic regression applied to assess the relationship between allele frequency and clinical features in 139 BC patients. 30006972 2019
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.020 GeneticVariation disease BEFREE PCR-Restriction Fragment Length Polymorphism (RFLP) was used to genotype LIMK2 SNP rs2073859 and multivariate logistic regression applied to assess the relationship between allele frequency and clinical features in 139 BC patients. 30006972 2019
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.010 GeneticVariation disease BEFREE We detected genetic association between BD and LIMK2 (rs149034313), involved in regulating cytoskeletal reorganization, and between BD and NEIL1 (rs5745908), involved in base excision DNA repair (P = 3.22 × 10(-4) and P = 5.16 × 10(-4) , respectively). 26662719 2016
CUI: C0009319
Disease: Colitis
Colitis 		0.010 GeneticVariation disease BEFREE Limk2 deletion increased colon tumour size in a colitis-associated colorectal mouse cancer model. 23585469 2014
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.110 Biomarker disease BEFREE Although genome-wide significance with type 2 diabetes was not found for any of these 25 SNPs, several genes, including RPS12, LIMK2, and SFI1 are strong candidates for diabetic nephropathy. 21150874 2011
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE Further, we showed that LIMK2 was a downstream effector in the LINC00460-induced promotion of metastasis in CRC cells HT29 and LOVO. 30863183 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE LIM kinase 2 (LIMK2) promotes tumour cell invasion and metastasis. 23585469 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE BMPR2 promotes invasion and metastasis via the RhoA-ROCK-LIMK2 pathway in human osteosarcoma cells. 28938584 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE LIMK1 and, more recently, LIMK2 have been shown to be involved in cancer development and metastasis, resistance of cancer cells to microtubule-targeted treatments, neurological diseases, and viral infection. 30373762 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE Gain- and loss-of-function assays revealed that LIMK2 inhibits cell proliferation via cell cycle arrest at the G1-S transition and suppresses the ability of cell metastasis by restricting the EMT process. 29970879 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE Both LIMK1 and LIMK2 single knock down led to a reduction of invasion and metastatic behavior in the zebrafish xenograft metastasis assay. 20047470 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways. 30886151 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 Biomarker phenotype BEFREE LIM kinase 2 (LIMK2) promotes tumour cell invasion and metastasis. 23585469 2014
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 Biomarker phenotype BEFREE While knockdown of either LIMK1 or LIMK2 only minimally influenced invasion in culture, simultaneous knockdown of both isoforms strongly reduced the invasive motility of continuous culture models and human GBM tumor-initiating cells (TIC) in both Boyden chamber and 3D hyaluronic acid spheroid invasion assays. 31641031 2020
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 Biomarker phenotype BEFREE LIMK2 overexpression promoted proliferation, migration and invasion of BC cells, while LIMK2 depletion inhibited cell invasion and viability and induced growth arrest in vitro and in vivo. 30006972 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 Biomarker phenotype BEFREE BMPR2 promotes invasion and metastasis via the RhoA-ROCK-LIMK2 pathway in human osteosarcoma cells. 28938584 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 Biomarker phenotype BEFREE Both LIMK1 and LIMK2 single knock down led to a reduction of invasion and metastatic behavior in the zebrafish xenograft metastasis assay. 20047470 2009
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 Biomarker phenotype BEFREE Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways. 30886151 2019